Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.


Doses - METHIONINE, DL-METHIONINE

Dogs:

For urine acidification:
a) In struvite dissolution therapy if diet and antimicrobials do not result in acid urine: 0.2 - 1.0 grams PO q8h (Lage, Polzin, and Zenoble 1988), (Kirk 1986)

Cats:

For urine acidification:
a) 1000 - 1500 mg per day given in the food once daily (if diet and antimicrobials do notreduce pH) (Lewis, Morris, and Hand 1987)
b) 0.2 -1.0 grams PO once daily (Lage, Polzin, and Zenoble 1988)

Cattle:

a) 20 - 30 grams PO (Jenkins 1988)

Horses:

a) 22 mg/kg PO once daily for one week; then 11 mg/kg PO once daily for 1 week; then5.5 mg/kg PO once daily for one week. (Robinson 1987)
b) 12.5 grams IV in one liter saline/dextrose solution (may be effective in Senecio-inducedliver damage. (Rossoff 1974)
Monitoring Parameters -
  • 1) Urine pH (Urine pH's of ?6.5 have been recommended as goals of therapy)
  • 2) Blood pH if symptoms of toxicity are present
  • 3) CBC in cats exhibiting symptoms of toxicity
    Client Information - Give with meals or mixed in food, unless otherwise instructed by veterinarian.
    Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: Methionine is approved for use in dogs, cats, and horses inpharmaceutical dosage forms. Products labeled as nutritionals may be approved for use in otherspecies. Depending on the product, methionine may be available without prescription.
    Methionine Tablets 200 mg & 500 mg; Ammonil® (Daniels), Odor-Trol® (Miles), Methio-Tabs® (Vet-A-Mix) (Rx) Approved for use in cats and dogs
    Methionine Tablets Chewable 500 mg; Methio-Form® (Vet-A-Mix) Approved for use in dogs
    Methionine Powder, Granules, Pellets (concentration varies with product); Trade
    Names/Products include: Methio-Vet® Pellets (Vet-A-Mix) (OTC); Bio-Meth® (Vet-A-Mix)
    Approved for use in horses.

    Human-Approved Products:

    Methionine Capsules 200 mg, 500 mg; Tablets 500 mg; Liquid 75 mg/5 ml; May be availablegenerically labeled or tradenames may include: Pedameth® (Forest), Uracid® (Wesley),
    Uranap® (Vortech). Depending product, is either an OTC or Rx item.
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