Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.


Doses - METHOCARBAMOL

Dogs:

a) Injectable: For relief of moderate conditions: 44 mg/kg IV; For controlling severe effects of strychnine and tetanus: 55 - 220 mg/kg IV, do not exceed 330 mg/kg/day.
Administer half the estimated dose rapidly, then wait until animal starts to relax andcontinue administration to effect.
Tablets: Initially, 132 mg/kg/day PO divided q8h-q12h, then 61-132 mg/kg divided q8-12h. If no response in 5 days, discontinue. (Package insert; Robaxin®-V ¯Robins)
b) For muscle relaxation for intervertebral disk disease: 15 - 20 mg/kg PO tid.
For muscle relaxation for certain toxicosis (e.g., strychnine, metalaldehyde, tetanus):150 mg/kg IV (Morgan 1988)
c) For strychnine/brucine poisoning: Average first dose is 149 mg/kg IV, repeat half doseas needed (Bailey 1986a)

Cats:

a) Injectable: For relief of moderate conditions: 44 mg/kg IV; For controlling severe effects of strychnine and tetanus: 55 - 220 mg/kg IV, do not exceed 330 mg/kg/day.
Administer half the estimated dose rapidly, then wait until animal starts to relax andcontinue administration to effect.
Tablets: Initially, 132 mg/kg/day PO divided q8h-q12h, then 61 - 132 mg/kg divided q8-12h. If no response in 5 days, discontinue. (Package insert, Robaxin®-V ¯Robins)

Cattle:

For treatment of CNS hyperactivity:
a) 110 mg/kg IV (Bailey 1986b)

Horses:

a) For moderate conditions: 4.4 - 22 mg/kg IV to effect; for severe conditions: 22 - 55mg/kg IV (Package insert, Robaxin®-V ¯ Robins)
b) 15 - 25 mg/kg IV by slow infusion (Robinson 1987)
c) To give orally: Use 2-3 times the recommended IV dose. (Cunningham, Fisher et al. 1992)
Monitoring Parameters -
1) Level of muscle relaxation/sedation
Client Information - Animal's urine color may darken, but need not be of concern.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Methocarbamol Tablets 500 mg; Robaxin®-V (Fort Dodge); (Rx) Approved for use in dogs and cats.
Methocarbamol Injection 100 mg/ml in vials of 20 ml and 100 ml; Robaxin®-V (Fort Dodge);(Rx) Approved for use in dogs, cats, and horses not intended for food.

Human-Approved Products:

Methocarbamol Tablets 500 mg, 750 mg; Robaxin® (Robins); Robaxin-750® (Robins); Generic(Rx)
Methocarbamol Injection 100 mg/ml in 10 ml vials; Robaxin® (Robins); generic (Rx)
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