Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.


Doses - THIABENDAZOLE

Dogs:

As an antiparasitic agent:
a) For treatment of Strongyloides stercoralis: 50 - 60 mg/kg PO. (Todd, Paul, and DiPietro 1985)
b) For treatment of Filaroides infections: 30 - 70 mg/kg divided q12h PO in food for 20-45 days. (Roudebush 1985)
c) For treatment of Filaroides infections: 70 mg/kg PO bid for 2 days; then 35 mg/kg PObid for 20 days. (Morgan 1988)
d) 50 mg/kg PO once daily for 3 days; repeat in one month. (Kirk 1989)
As an antifungal agent:
a) For treatment of nasal aspergillosis/penicillinosis infections: 30 - 70 mg/kg dividedq12h PO in food for 20-45 days. (Roudebush 1985)
b) For the treatment of aspergillosis: 20 mg/kg PO, once a day or divided bid; (with orwithout ketoconazole: 20 mg/kg PO, once a day or divided bid). Maintenance therapy:10 - 20 mg/kg PO once a day. (Greene, O'Neal, and Barsanti 1984)
c) For penicillinosis: With appropriate adjunctive surgical curettage and topical therapy, thiabendazole: 20 mg/kg/day PO for 4-6 weeks. (Barsanti 1984)
d) For aspergillosis: Administer 10 mg/kg as nasal flush. Dilute in 10-20 ml of water.
Flush twice daily for 10 days.
Orally: 20 mg/kg/day divided bid for 6 weeks. (Morgan 1988)
e) For treatment of nasal aspergillosis: 20 mg/kg divided q12h PO for 6-8 weeks. Ifanorexia or nausea develop, may withdraw drug and then gradually reintroduce gradually to the full dosage. Administer with food to enhance absorption and reduceanorexia. May be effective in 40-50% of dogs treated. (Sharp 1989)

Cattle:

For susceptible parasites:
a) 66 mg/kg PO; 110 mg/kg PO for Cooperia and severe infections of other susceptiblenematodes. Retreat in 2-3 weeks if indicated. (Paul 1986), (Roberson 1988b)
b) 50 - 100 mg/kg PO. (Brander, Pugh, and Bywater 1982)

Horses:

For susceptible parasites:
a) 44 mg/kg PO. (Robinson 1987)
b) 44 mg/kg; 88 mg/kg for ascarids. (Roberson 1988b)
c) 50 - 100 mg/kg PO (Brander, Pugh, and Bywater 1982)

Swine:

For susceptible parasites:
a) For baby pigs with Strongyloides ransomi: 62 - 83 mg/kg PO, retreat in 5-7 days ifnecessary. To prevent Ascaris suum: Feed at 0.05 - 0.1% per ton of feed for 2 weeks, then 0.005 - 0.02% per ton for 8-14 weeks. (Paul 1986)
b) 75 mg/kg PO (Roberson 1988b)
c) 50 mg/kg PO. (Brander, Pugh, and Bywater 1982)

Sheep & Goats:

For susceptible parasites:
a) 44 mg/kg PO; 66 mg/kg PO for severe infections in goats. (Paul 1986), (Roberson1988b)
b) 50 - 100 mg/kg PO (sheep). (Brander, Pugh, and Bywater 1982)
Llamas:
For susceptible parasites:
a) 50 - 100 mg/kg PO for 1-3 days. Use higher dosage rate over several days when animalis severely parasitized. (Cheney and Allen 1989)
b) 66 mg/kg PO. (Fowler 1989)

Birds:

For susceptible parasites:
a) For ascarids: 250 - 500 mg/kg PO once. Repeat in 10-14 days.
For Syngamus trachea: 100 mg/kg PO once a day for 7-10 days. (Clubb 1986)
b) For ascarids, Capillaria, gapeworms:
Chickens, pheasants, turkeys, and pigeons: Mix 0.5% in feed for 10 days or administerorally at 44 mg/kg as a single dose.
Psittacines: 44 mg/kg PO; do not exceed this dose.
Falcons: 100 mg/kg PO as a single dose. (Stunkard 1984)
c) For thorny headed worms in water fowl and raptors: 250 mg/lb. (Stunkard 1984)
Client Information - Shake suspension well before using. Follow veterinarian's or label directions carefully.
Dosage Forms/Preparations/FDA Approval Status/Withdrawal Times- Food residue tolerances: 0.1 ppm in uncooked meat of cattle, pheasants, swine, sheep and goats. 0.05 ppm in milk.
Veterinary-Approved Products:
Thiabendazole Oral Suspension 4 g/fl. oz. (135 mg/ml)
Equizole® Suspension (MSD); (OTC) Approved for use in dairy and beef cattle, sheep, goats, and horses. Milk withdrawal = 96 hours. Slaughter withdrawal = 3 days (cattle); 30days (sheep & goats)
Thiabendazole Oral Suspension 6 g/fl. oz. (203 mg/ml)
Omnizole®-Six Wormer Suspension (MSD); (OTC) Approved for use in dairy and beefcat le, sheep, goats, and horses. Milk withdrawal = 96 hours. Slaughter withdrawal = 3days (cattle); 30 days (sheep & goats)
Thiabendazole Oral Suspension (Drench) 25 g/fl. oz. (845 mg/ml)
TBZ® Cattle Wormer (Drench) (MSD); (OTC) Approved for use in dairy and beef cattle.
Milk withdrawal = 96 hours. Slaughter withdrawal = 3 days
Thiabendazole Oral Suspension 17.5 g/fl. oz. (592 mg/ml)
Thibenzole® Sheep and Goat Wormer (MSD); (OTC) Approved for use in sheep and goats.
Milk withdrawal = 96 hours. Slaughter withdrawal = 30 days
Thiabendazole Oral Paste 50% (500 mg/g), 43% (430 mg/g), 20% (200 mg/g)
TBZ® Cattle Wormer Paste 50%, TBZ® Wormer Paste 43% (MSD); (OTC) Approved foruse in dairy and beef cattle. Milk withdrawal=96 hours. Slaughter withdrawal = 3 days
Thiabendazole Oral Boluses (Tablets) 15 g (cattle), 2 g (calf, sheep, goat)
TBZ® Calf, Sheep, and Goat Wormer (MSD); (OTC) Approved for use in non-lactatingdairy and beef cattle, goats, and sheep. Slaughter withdrawal = 3 days (calves); 30 days(goats, sheep)
Thiabendazole Medicated Premixes are available in: 22%, 44.1%, 66.1%, 88.2% concentrations.
A thiabendazole medicated block (15 g/lb) is also available. An oral suspension of thiabendazole (2 g/oz) in combination with piperazine (2.5 g/oz) is available for use in horses. Itis a prescription only medication (Rx) with the proprietary name: Equizole® A (MSD).

Human-Approved Products:

Thiabendazole Oral Chewable Scored Tablets 500 mg; Mintezol® (Merck); (Rx)Thiabendazole Oral Suspension 100 500 mg/5 ml, 120 ml bottle; Mintezol® (Merck); (Rx)