CEFADROXIL
For general information on the cephalosporins including adverse effects, contraindications, overdosage, drug interactions, and monitoring parameters, refer to the monograph: Cephalosporins, General Information.
Chemistry - A semisynthetic cephalosporin antibiotic, cefadroxil occurs as a white to yellowish-white, crystalline powder that is soluble in water and slightly soluble in alcohol. The commercially available product is available as the monohydrate.
Pharmacology/Spectrum of Activity - A first generation cephalosporin, cefadroxil exhibits activity against the bacteria usually covered by this class. Refer to the monograph: Cephalosporins,
General Information for additional information.
Uses, Indications - Cefadroxil is approved for oral therapy in treating susceptible infections of theskin, soft tissue, and genitourinary tract in dogs. It has also been used clinically in cats.
Pharmacokinetics (specific) - Cefadroxil is reportedly well absorbed after oral administration todogs without regard to feeding state. After an oral dose of 22 mg/kg, peak serum levels of approximately 18.6 micrograms/ml occur within 1-2 hours of dosing. Only about 20% of the drug isbound to canine plasma proteins. The drug is excreted into the urine and has a half-life of about 2hours. Over 50% of a dose can be recovered unchanged in the urine within 24 hours of dosing.
In cats, the serum half-life has been reported as approximately 3 hours.
Oral absorption of cefadroxil in adult horses after oral suspension was administered was characterized as poor and erratic. In a study done in foals (Duffee, Christensen, and Craig 1989), oralbioavailability ranged from 36-99.8% (mean=58.2%); mean elimination half-life was 3.75 hoursafter oral dosing.
Chemistry - A semisynthetic cephalosporin antibiotic, cefadroxil occurs as a white to yellowish-white, crystalline powder that is soluble in water and slightly soluble in alcohol. The commercially available product is available as the monohydrate.
Storage, Stability, Compatibility
Cefadroxil tablets, capsules and powder for oral suspension should be stored at room temperature (15-30°C) in tight containers. After reconstitution, the oral suspension is stable for 14 days when kept refrigerated (2-8°C).Pharmacology/Spectrum of Activity - A first generation cephalosporin, cefadroxil exhibits activity against the bacteria usually covered by this class. Refer to the monograph: Cephalosporins,
General Information for additional information.
Uses, Indications - Cefadroxil is approved for oral therapy in treating susceptible infections of theskin, soft tissue, and genitourinary tract in dogs. It has also been used clinically in cats.
Pharmacokinetics (specific) - Cefadroxil is reportedly well absorbed after oral administration todogs without regard to feeding state. After an oral dose of 22 mg/kg, peak serum levels of approximately 18.6 micrograms/ml occur within 1-2 hours of dosing. Only about 20% of the drug isbound to canine plasma proteins. The drug is excreted into the urine and has a half-life of about 2hours. Over 50% of a dose can be recovered unchanged in the urine within 24 hours of dosing.
In cats, the serum half-life has been reported as approximately 3 hours.
Oral absorption of cefadroxil in adult horses after oral suspension was administered was characterized as poor and erratic. In a study done in foals (Duffee, Christensen, and Craig 1989), oralbioavailability ranged from 36-99.8% (mean=58.2%); mean elimination half-life was 3.75 hoursafter oral dosing.