Doses - CIMETIDINE, CIMETIDINE HCL

Dogs:

For esophagitis:
a) 5 - 10 mg/kg PO q6h (do not give with antacids) (Jones 1985)
b) 4 mg/kg PO qid (Watrous 1988)
For prevention of drug-induced gastric erosion/ulceration: 5 mg/kg PO, SQ, tid (Schunk1988)
For chronic gastritis:5 - 10 mg/kg PO, IM or IV tid-qid (Hall and Twedt 1988)
For ulcer disease:
a) 5 - 10 mg/kg PO, IM or IV tid-qid (Hall and Twedt 1988)
b) 4 - 5 mg/kg PO, IV, or SQ tid-qid (Chiapella 1988)
c) 5 mg/kg IV or PO qid (Moreland 1988)
d) 5 - 10 mg/kg PO q6-8h or 10 mg/kg q6h as a slow (over 30 minutes) IV infusion(DeNovo 1986)
e) 10 mg/kg PO, IM, IV q8h (Matz 1995)
For gastrinoma: 5 - 15 mg/kg IV, SQ or PO qid (Kay, Kruth, and Twedt 1988)
To prevent histamine-mediated gastric hyperacidity/ulceration secondary to mast cell tumors:
a) 5 mg/kg q8h (Fox 1995b)
b) 5 mg/kg PO, IV, tid-qid (Stann 1988)
To decrease gastric acid hypersecretion during the treatment of alkalosis: 5 - 10 mg/kg tid-qid (Hardy and Robinson 1986)
As an immunomodulating agent (reverses suppressor T cell-mediated immune suppression):
a) 10 - 25 mg/kg PO bid (Desiderio and Rankin 1986)

Cats:

a) 5 - 10 mg/kg PO q6-8h or 10 mg/kg q6h as a slow (over 30 minutes) IV infusion (DeNovo 1986)

Cattle:

To treat abomasal ulcers: 8 - 16 mg/kg tid (method of administration not specified); relativelyexpensive and may be only of minimal value (Whitlock 1986a)

Horses:

For foals:
a) 1000 mg divided bid or tid PO, IV or IM (Robinson 1987)
b) 300 - 600 mg PO or IV 4 times a day (Clark and Becht 1987)

Swine:

To treat gastric ulcers: 300 mg per animal twice daily (Wass et al. 1986b)

Reptiles:

In most species: 4 mg/kg PO q8-12h (Gauvin 1993)
Monitoring Parameters -

1) Clinical efficacy (dependent on reason for use); monitored by decrease in symptomatology, endoscopic examination, blood in feces, etc.

2) Adverse effects if noted
Client Information - To maximize the benefit of this medication, it must be administered asprescribed by the veterinarian; symptoms may reoccur if dosages are missed.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Cimetidine Tablets 100 mg, 200 mg, 300 mg, 400 mg, 800 mg; Tagamet® HB (SKBeecham)(OTC); Tagamet® (SK-Beecham) (Rx); generic (Rx)
Cimetidine HCl Liquid 300 mg (as HCl) per 5 ml; Tagamet® (SK-Beecham) (Rx); Cimetidine
Oral Solution® (Barre-National) (Rx)
Cimetidine HCl for Injection 150 mg/ml in 2 ml vials and 8 ml multiple-dose vials and 8 mlvials; 300 mg (as HCl) in 50 ml 0.9% sodium chloride in premixed single-dose containers;
Tagamet® (SK-Beecham) (Rx);Cimetidine® (Endo) (Rx)