Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

ALBENDAZOLE

Chemistry - A benzimidazole anthelmintic structurally related to mebendazole, albendazole has a molecular weight of 265. It is insoluble in water and soluble in alcohol.

Storage, Stability, Compatibility

Albendazole suspension should be stored at room temperature(15-30°C); avoid freezing. Shake well before using.

Uses, Indications

Albendazole is approved for the following endoparasites of cattle: Ostertagia ostertagi, Haemonchus spp., Trichostrongylus spp., Nematodius spp., Cooperia spp.,
Bunostomum phlebotomum, Oesphagostomum spp., Dictacaulus spp., Fasciola hepatica (adults), and Moniezia spp. It is also used in sheep, goats and swine for endoparasite control.
In cats, albendazole has been used to treat Paragonimus kellicotti infections. In dogs and cats, albendazole has been used to treat capillariasis. In dogs, albendazole has been used to treat
Filaroides infections.
Albendazole was implicated as being an oncogen in 1984, but subsequent studies were unable to demonstrate any oncogenic or carcinogenic activity of the drug.

Pharmacokinetics - ALBENDAZOLE

Pharmacokinetic data for albendazole in cattle, dogs and cats were not located.
The drug is thought to be better absorbed orally than other benzimidazoles. Approximately 47% of an oral dose was recovered (as metabolites) in the urine over a 9 day period.
After oral dosing in sheep, the parent compound was either not detectable or only transiently detectable in the plasma due to a very rapid first-pass effect. The active metabolites, albendazole sulphoxide and albendazole sulfone reached peak plasma concentrations 20 hours after dosing.
Contraindications/Precautions - The drug is not approved for use in lactating dairy cattle. The manufacturer recommends not administering to female cat le during the first 45 days of pregnancy or for 45 days after removal of bulls. Albendazole has been associated with teratogenic and embryotoxic effects in rats, rabbits and sheep when given early in pregnancy.
In humans, albendazole is recommended to be used with caution in patients with liver or hematologic diseases.

Adverse Effects, Warnings

Albendazole is tolerated without significant adverse effects when dosed in cattle at recommended dosages.
Dogs treated at 50 mg/kg twice daily may develop anorexia.
Cats may exhibit symptoms of mild lethargy, depression, anorexia, and resistance to taking the medication when albendazole is used to treat Paragonimus.
Overdosage/Toxicity - Doses of 300 mg/kg (30X recommended) and 200 mg/kg have caused death in cattle and sheep, respectively. Doses of 45 mg/kg (4.5X) those recommended did not cause any adverse effects in cattle tested. Cats receiving 100 mg/kg/day for 14-21 days showed signs of weight loss, neutropenia and mental dullness.

Drug Interactions

In humans, dexamethasone and praziquantal both have been demonstrated to increase albendazole serum levels. Cimetidine increased albendazole levels in bile and cystic fluid. Veterinary clinical relevance is unknown.
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