Doses - DOXYCYCLINE CALCIUM, DOXYCYCLINE HYCLATE, DOXYCYCLINE MONOHYDRATE

Dogs:

For susceptible infections:
a) 5 mg/kg PO or IV q12h; administer with food if GI upset occurs; avoid in young animals; avoid or reduce dose in animals with severe liver disease (Vaden and Papich 1995)
b) For canine ehrlichiosis: 5 - 10 mg/kg every 12-24 hours for 2-3 months (duration oftreatment based upon preliminary data). (Greene 1995)
c) For canine ehrlichiosis: 5 mg/kg PO, IV once daily for 7 days in acute cases, and 10mg/kg PO once daily for 7-21 days in chronic cases. (Morgan 1988)
d) For Lyme Disease: 10 mg/kg PO q24h for 21-28 days (Appel and Jacobson 1995)
e) For salmon poisoning disease: 10 mg/kg IV twice a day for at least 7 days. (Rikihisaand Zimmerman 1995)

Cats:

For susceptible infections:
a) 5 mg/kg PO or IV q12h; administer with food if GI upset occurs; avoid in young animals; avoid or reduce dose in animals with severe liver disease (Vaden and Papich 1995)
b) 5 mg/kg PO q12h (Davis 1985)
c) For feline ehrlichiosis: 5 mg/kg twice daily (Kordick, Lappin et al. 1995)

Horses:

Warning: Doxycycline intravenously in horses has been associated with fatalities. Untilfurther work is done demonstrating the safety of this drug, it cannot be recommendedfor parenteral use in this species.

Birds:

For Psittacosis (Chlamydiosis):
a) In psittacines: 25 mg/kg PO bid or 50 mg/kg PO once daily using the oral syrup orsuspension. Emesis may occur. Increase dosage if giving with gavage formula. Incritically ill birds (either confirmed or suspected of psittacosis) 20 mg/kg IV once onlymay be administered; followed with oral therapy. (McDonald 1989)
b) In psittacines: 17.6 - 26.4 mg/kg PO bid using the oral syrup or suspension. For initialtherapy in severe cases: 22 - 44 mg/kg IV once or twice; do not give IM. Long termtherapy (45 days) can be given as 200 mg (from capsules) per pound of food. (Clubb1986)
c) Using the oral liquid/suspension: 50 mg/kg PO every 24 hours, or divided every 12hours (use less for macaws).
Using the hyclate salt on on corn, beans, rice and oatmeal: 1 gram per kg of feed.
Using the injectable product (Vibaravenos®-may not be available commercially in the
USA): 100 mg/kg IM once weekly (75 mg/kg IM once weekly in macaws and lovebirds) (Bauck and Hoefer 1993)

Reptiles:

For susceptible infections:
a) For chelonians: 10 mg/kg PO once daily for 4 weeks. Useful for bacterial respiratoryinfections in tortoises having suspected Mycoplasma infections.
In most species: 10 mg/kg PO once daily for 10-45 days (Gauvin 1993)
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects
Client Information - Oral doxycycline products may be administered without regard to feeding.
Milk or other dairy products do not significantly alter the amount of doxycycline absorbed.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Doxycycline (as the hyclate) Tablets and Capsules 50 mg, 100 mg; Vibramycin®(Pfizer);
Doxychel® Hyclate (Rachelle), Doxy Caps® (Edwards); Bio-Tab® (Inter. Ethical Labs); Vibra-
Tabs® (Pfizer); generic; (Rx)
Doxycycline (as monohydrate) Tablets and Capsules 50 mg, 100 mg; Monodox® (Oclassen) (Rx)
Doxycycline coated pellets (as hyclate) 100 mg; Doryx® (Parke-Davis) (Rx)
Doxycycline (as the monohydrate) Powder for Oral Suspension 5 mg/ml 25 mg/5 ml after reconstitution in 60 ml bottles
Vibramycin® (Pfizer); (Rx)
Doxycycline (as the calcium salt) Oral Syrup 10 mg/ml in 50 ml bottles. Vibramycin® (Pfizer); (Rx)
Doxycycline (as the hyclate) Powder for Injection 100 mg and 200 mg vials
Vibramycin® IV (Roerig); Doxychel® Hyclate (Rachelle); Doxy 100 & 200 (Lyphomed); generic; (Rx)