Doses - EDROPHONIUM CHLORIDE

Dogs:

For presumptive diagnosis of myasthenia gravis (MG):
a) Inject 0.1 - 0.2 mg/kg IV; short term increased muscle strength is seen in a positive (notnecessarily specific for MG, both false positives and negatives) test. (Shelton 1992)
b) 0.11 - 0.22 mg/kg IV (Papich 1992)

Cats:

For presumptive diagnosis of myasthenia gravis (MG):
a) 2.5 mg IV (Papich 1992)
b) 0.25 - 0.5 mg per cat IV (Joseph, Carrillo et al. 1988)
Monitoring Parameters - Dependent on its indication. See doses above.
Client Information - Edrophonium is a drug that should be used in a controlled clinical setting.
Clients should be briefed on the side effects that can occur with its use.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Edrophonium Chloride for Injection 10 mg/ml in one ml amps and 10 ml & 15 ml vials;
Tensilon® (ICN), Enlon® (Ohmeda); Reversol® (Organon); (Rx)
Edrophonium Chloride for Injection 10 mg/ml with 0.14 mg/ml Atropine Sulfate; in 5 ml ampsand 15 ml vials Enlon-Plus® (Ohmeda); (Rx)
EFA-Caps® - see Fatty Acids