FATTY ACIDS, ESSENTIAL / OMEGA, FISH OIL / VEGETABLE OIL DIETARY SUPPLEMENTS

Chemistry - The commercially available veterinary products generally contain a combination offish oil (eicosapentaenoic and docosahexanoic acids), vegetable oil (gamma linolenic acid) whichserve as essential fatty acids. They may also contain vitamin E (d-alpha tocopherol) and vitamin A.

Storage, Stability, Compatibility

The oral capsules should be stored in tight containers andprotected from heat (cool, dry place).

Pharmacology - FATTY ACIDS, ESSENTIAL/OMEGA, FISH OIL/VEGETABLE OIL DIETARY SUPPLEMENTS

The exact pharmacologic actions of these products are not well described; particularly in light of the combination nature of the commercial products being marketed it is difficult to ascertain which compounds may be responsible for their proposed efficacy.
Fish oils affect arachidonic acid levels in plasma lipids and platelet membranes. They may affectproduction of inflammatory prostaglandins in the body, thereby reducing inflammation andpruritus. Linolenic or linoleic acids may be used as an essential fatty acid source which are necessary for normal skin and haircoats.
Uses, Indications - These products are generally indicated for the treatment of pruritus associated with atopy, and idiopathic seborrhea; and pruritus in cats for the adjunctive treatment of miliary dermatitis and eosinophilic granuloma complex.

Contraindications, Precautions, Reproductive Safety

Safe use in pregnancy has not been established; these products are not recommended for use in pregnant human patients.

Adverse Effects, Warnings

At high dosages, GI disturbances (e.g., vomiting, diarrhea) may beseen. Rarely, some dogs become lethargic or more pruritic. In human patients, increased bleedingtimes and decreased platelet aggregation have been noted with use of fish oils; use with caution inpatients with coagulopathies.

Overdosage, Acute Toxicity

With products containing vitamin A, acute toxicosis may result afteraccidental overdoses. Contact a poison control center for additional information.

Drug Interactions

Because of potential affects on bleeding times, use with caution in patientsreceiving anticoagulant medications such as aspirin, warfarin or heparin.