Doses - FOLLICLE STIMULATING HORMONE-PITUITARY (FSH-P)

Dogs:

For induction of estrus:
a) 20 IU/kg SQ (must convert Armour Units to IU; contact manufacturer to determinepotency of lot number) for 10 days. Proestrus usually occurs between days 7-10 andlasts 2-3 days. Give human chorionic gonadotropin (HCG) 500 IU SQ on days 10 and11; breed on days 12, 14, and 16. (Barton and Wolf 1988)
For labeled indications (FSH deficiency):
a) 5 -15 mg IV, IM or SQ (Package Insert; F.S.H.-P. ¯Schering)

Cats:

To induce estrus in anestrus queens:
a) FSH: 2 mg IM daily for up to 5 days until estrus observed, then give hCG on first andsecond day of estrus. (Kraemer and Bowen 1986)
To stimulate follicle maturation and estrous behavior in cats:
a) FSH-P 2 mg IM once daily for 5 days, may reduce dosage to 0.5 or 1 mg on the 2nd-5th day. Do not use longer than 5 days. Discontinue as soon as female is sexually receptive and mates. Most queens are in estrus within 5-6 days after treatment has begunand will remain sexually receptive for approximately 6 days. If female fails to exhibitestrual behavior with 7 days after last injection, may repeat treatment regimen in 5-6weeks. (Wildt 1986)

Cattle:

For induction of superovulation:
a) For induction of superovulation: Reconsitute as directed on label, then inject 1.6 ml IMtwice a day for 3 days. At the fifth injection give a lutalyzing dose of prostaglandin permanufacturer's directions to induce estrus. Breed 4 - 22 hours after onset of estrus.(Package Insert; Super-OV®¯AUSA Int.)
b) If estrus = day 0, institute treatment between days 8-14 (usually day 10). Two methodsused; method 1 is simpler, but may be less desirable.
Method 1: Give FSH 5 mg IM or SQ twice daily beginning on day 10 through day 13.
Perform AI during the PM of days 14 and AM and PM of day 15.
Method 2: Give FSH 5 mg AM and PM on day 10; 4 mg AM and PM on day 11; 3 mg
AM and PM on day 12; 2 mg AM and PM on day 13. Perform AI during the PM ofdays 14 and AM and PM of day 15. (Mapletoff 1986)
For labeled indications (FSH deficiency):
a) 10 - 50 mg IV, IM or SQ (Package Insert; F.S.H.-P. ¯Schering)

Horses:

For labeled indications (FSH deficiency):
a) 10 - 50 mg IV, IM or SQ (Package Insert; F.S.H.-P. ¯Schering)

Swine:

For labeled indications (FSH deficiency):
a) 5 - 25 mg IV, IM or SQ (Package Insert; F.S.H.-P. ¯Schering)

Sheep:

For labeled indications (FSH deficiency):
a) 5 - 25 mg IV, IM or SQ (Package Insert; F.S.H.-P. ¯Schering)

Rabbits:

For induction of superovulation:
a) FSH: 0.5 mg injected bid for days, followed by LH: 1.5 mg/kg IV or hCG: 30 - 50 IU, 12-24 hours after last FSH dose. Will produce 40-60 ovulations. (Kraemer and Bowen 1986)
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: Note: The ongoing availability of FSH-P products has been reported to be an issue; these products may or may not be avialable in the marketplace. Check with suppliers for more information.
Follicle Stimulating Hormone-Pituitary (FSH-P) lyophilized powder for reconstitution and injection. Each vial contains 50 mg Armour Standard and is packaged with one 10 ml vial of diluent (sodium chloride injection).; F.S.H.-P. (Schering) (Rx) Approved for use in cattle, horses, swine, sheep, and dogs.
Follicle Stimulating Hormone Each vial contains 75 mg NIH-FSH-S1 Standard and is packaged with one 10 ml vial of buffered diluent .; Super-OV® (AUSA Int.) (Rx) Approved foruse in cattle. No milk or meat withdrawal periods are required when used as directed.
Human-Approved Products: None