Doses - HYALURONATE SODIUM, SODIUM HYALURONATE

Horses: Because of the differences in the commercially products see each individual product'slabel for specific dosing information.

Dogs:

For the adjunctive treatment of synovitis (rather than the presence of a damaged articularcartilage):
a) Using a high molecular weight compound: 3 - 5 mg intra-articularly using steriletechnique at weekly intervals. Long term effects are not achieved. (Bloomberg 1992)
Client Information - HS should be administered by a veterinarian only using aseptic technique.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Hyaluronate Sodium (average MW of 500, 000 - 730, 000) 20 mg/ml in 2 ml disposable syringes; Hyalovet® (Fort Dodge); (Rx)
Hyaluronate Sodium Injection Legend® (Bayer) (Rx); 2 ml vial for IA administration; 4 ml vialsfor IV administration. Approved for use in horses.
Also available Hyvisc® (Boehringer Ingelheim) (Rx)Hyaluronate Sodium 10 mg/ml (MW 3.5 x 106) in 2 ml disposable syringes; Hylartin®(Pharmacia & Upjohn); (Rx)
All the above products are approved for use in horses. Not for use in horses intended for food.