IMIDACLOPRID
Chemistry/Storage, Stability, Compatibility
Imidacloprid is a chloronicotinyl nitroguanidine insecticidal agent synthesized from the nitromethylene class of compounds. Its chemical formula is 1-[(6-Chloro-3-pyridinyl) methyl] - N-nitro-2-imidazolidinimine. The commercially available product should be stored in a cool, dry area.Pharmacology - IMIDACLOPRID
Imidacloprid's mechanism of action as an insecticide is to act on nicotinicacetylcholine receptors on the postsynaptic membrane causing CNS impairment and death. Certaininsect species are more sensitive to these agents than are mammalian receptors. This is a differentmechanism of action than other insecticidal agents (organophosphates, pyrethrins, carbamates, insect growth regulators (IGR's) and insect development inhibitors (IDI's). The manufacturer statesthat imidacloprid is non-teratogenic, non-hypersensitizing, non-mutagenic, non-allergenic, non-carcinogenic and non-photosensitizing. Imidacloprid does not have activity against ascarids.Uses, Indications
Imidacloprid topical solution is indicated for the treatment of adult and larvalstage fleas in dogs and cats.Pharmacokinetics - IMIDACLOPRID
The manufacturer states that when applied topically the compound is notabsorbed into the bloodstream or internal organs.Contraindications, Precautions, Reproductive Safety
The manufacturer lists the followingcontraindications to the compound: do not use on debilitated, aged, pregnant, or nursing animalsand do not use on kittens or puppies less than 4 months of age. However, other information provided by the manufacturer states that the compound is safe to use in puppies as young as 7 weeksold and kittens as young as 8 weeks old and can be safely used in geriatric dogs and cats.While the manufacturer states that the drug is not teratogenic, it also states not to use on pregnantanimals. Use during pregnancy only when the benefits outweigh the potential risks of therapy.
Adverse Effects, Warnings
When used as directed, no adverse effects were noted. Because thedrug is bitter tasting, oral contact may cause excessive salivation. Do not get product in eyes. Ifeye contact occurs (human or animal), flush well with ophthalmic irrigation solution or water.Human exposure: While gloving is not required, avoid contact with skin, and wash hands withsoap and water after handling. Keep out of reach of children and do not contaminate feed or food.
Overdosage - Limited data are available, but animals administered up to 5X overdoses topically, didnot demonstrate overt adverse effects.