Doses - ISOFLURANE
Dogs & Cats:
(Note: Concentrations are dependent upon fresh gas flow rate; the lower the flow rate, the higher the concentration required.) a) 5% induction; 1.5 - 2.5% maintenance (Papich 1992)
b) 0.5 - 3 %, inhaled (Hubbell 1994)
Pocket Pets:
a) Using a non-rebreathing system: Induction: 2 - 3%, maintenance: 0.25 - 2% (Anderson 1994)
Reptiles:
a) Give 5% isoflurane and oxygen in a clear plastic bag or induction chamber. Fillchamber with gas and seal. Induction time may take 30 - 60 minutes, but can beshortened to 15 - 30 minutes with increased depth of anesthesia if animal is injectedwith 10-20 mg/kg of ketamine (SubQ or IM). Patient should be kept warm by placingon a water blanket. Surgical anesthesia can be determined by the loss of righting reflex. After induction, use either a mask, ET tube, or leave head in chamber. Maintenancelevels are 3-5% (if isoflurane used alone). If apnea occurs during or after anesthesia, discontinue gas anesthetic and apply gentle manual ventilation 2 - 4 times per minutewith small doses of doxapram IV. Normal respiration generally resumes in 3-5 minutes.
Righting reflex generally recovers in an hour, but animal may be tranquilized for 24hours. (Gillespie 1994)
Birds:a) Small birds can be anesthetized safely in 15-30 seconds at 4% (Ludders 1992)
Monitoring Parameters - 1) Respiratory and ventilatory status; 2) Cardiac rate/rhythm; bloodpressure (particularly with "at risk" patients; 3) Level of anesthesia
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Isoflurane in 100 ml bottles; Aerrane® (Anaquest; Isovet® (Schering) (Rx) Approved for use indogs and cats.; IsoFlo® (Abbott) (Rx); Approved for dogs and horses.