Doses - ITRACONAZOLE

Dogs:

For systemic mycoses:
a) 5 mg/kg PO once or twice daily; consider adding amphotericin in rapidly progressive, life threatening infections. (Sherding and Johnson 1994b);
b) 5 mg/kg PO once to twice daily; author usually recommends higher dsoage rate andreduce if toxicity develops (Legendre 1995)

Cats:

For susceptible systemic mycoses:
a) 5 mg/kg PO once to twice daily; author usually recommends higher dsoage rate andreduce if toxicity develops. Cats will eat the pellets (found within the capsules) if placedinto food (Legendre 1995)
For generalized dermatophytosis:
a) 10 mg/kg PO once daily (Medleau and Moriello 1992)
For systemic mycoses:
a) 5 mg/kg PO once or twice daily; consider adding amphotericin in rapidly progressive, life threatening infections. (Sherding and Johnson 1994b)
For systemic mycoses, generalized dermatophytosis, dematiaceous fungi:
a) 5 - 10 mg/kg PO q12-24h (Wolf 1994)

Horses:

For aspergillosis:
a) 3 mg/kg twice a day (Legendre 1993)
A method to prepare an itraconazole suspension has been provided by the manufacturer with thefollowing caveats: 1) No bioavailability data available; 2) Use only if no other alternative.
Empty 24 (twenty four) 100 mg capsules into a glass mortar. Add 4 to 5 ml of 95% ethylalcohol USP and let stand 3 to 4 minutes to soften. Grind to a heavy paste; this willleave a powder when the alcohol dries. Slowly triturate with 15 ml of simple syrup.
Transfer to a 60 ml amber bottle and continue to rinse mortar with simple syrup to get 60 ml. Shake Well and Refrigerate. Discard after 35 days. Janssen Corp.: 1-800-526-7736
Monitoring Parameters - 1) Clinical Efficacy; 2) With long-term therapy, routine liver function tests are recommended (monthly ALT) 3) Appetite 4) Physical asssessment for ulcerative skin lesions in dogs
Client Information - Compliance with treatment recommendations must be stressed. Have clients report any potential adverse effects. Give with food.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Itraconazole Oral Capsules 100 mg; Sporanox® (Janssen); (Rx)