Doses - MILBEMYCIN OXIME

Dogs:

For prevention of heartworm:
a) 0.5 - 0.99 mg/kg PO once monthly (also controls hookworm, roundworm and whipworm infestations) (Calvert 1994)
For microfilaricide chemotherapy:
a) In adulticide -pretreated dogs: Use preventative/prophylaxis dosage; repeat in 2 weeks ifnecessary. If heartworm transmission season has started, continue monthly prohylaxis.(Knight 1995)
For treatment of generalized demodicosis:
a) 0.5 - 1 mg/kg PO once daily for at least 90 days (Miller 1992)
b) 1 mg/kg PO daily for one month past the point of negative skin scrapings. (Mundell1994)

Cats:

For prevention of heartworm:
a) 0.5 - 0.99 mg/kg PO once monthly (Miller 1994)
Client Information - Review importance of compliance with therapy and to be certain that thedose was consumed.
Dosage Forms/Preparations/FDA Approval Status - Veterinary-Approved Products:
Milbemycin Oxime Oral Tablets 2.3 mg, 5.75 mg, 11.50 mg, 23 mg; Interceptor®; Safeheart®(Novartis); (Rx) Approved for use in dogs.
Milbemycin/Lufenuron Oral Tablets in six tablet cards: 2.3 mg/46 mg (for dogs 2 to 10lbs., ¯brown), 5.75 mg/115 mg (for dogs 11 to 25 lbs., ¯green), 11.5 mg/230 mg (for dogs26 to 50 lbs., ¯yellow), 23 mg/460 mg (for dogs 51 to 100 lbs., ¯white); (Rx) Sentinel®(Novartis). Approved for use in dogs.
Human-Approved Products: None