Doses - NALOXONE HCL

Dogs & Cats:

For opioid reversal:
a) 0.002 - 0.02 mg/kg IV or IM; duration of effect 0.5-1 hour. (Bednarski 1989)
b) Dogs: 0.04 mg/kg IV, IM or SQ (Package Insert; P/M® Naloxone HCl Injection¯P/M; Mallinckrodt), (Kirk 1989)
c) Cats: 0.05 - 0.1 mg/kg IV (Muir and Swanson 1989)
d) 0.02 - 0.04 mg/kg IV (Morgan 1988)
Rabbits/Rodents/Pocket Pets:
For opioid reversal in rodents: 0.01 -0.1 mg/kg SubQ or IP as needed (Huerkamp 1995)

Horses:

For opioid reversal:
a) 0.01 - 0.022 mg/kg to reverse sedative and excitatory effects of narcotic agonists. (Clarkand Becht 1987)
b) 0.01 mg/kg IV to limit increases in locomotor activity secondary to narcotic agonists.(Muir 1987)
c) 0.01 - 0.02 mg/kg IV (Robinson 1987)
Monitoring Parameters -

1) Respiratory rate/depth

2) CNS function

3) Pain associated with opiate reversal
Client Information - Should be used with direct professional supervision only.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Naloxone HCl Injection 0.4 mg/ml in 10 ml vials; P/M® Naloxone HCl Injection (Schering
Plough); (Rx) Approved for use in dogs.

Human-Approved Products:

Naloxone HCl Injection 0.4 mg/ml in 1 ml amps, syringes & 1, 2, & 10 ml vials; Narcan®(Dupont Pharm.), Generic; (Rx)
Naloxone HCl Injection 1 mg/ml in 2 ml amps, vials & 1, 5, & 10 ml vials; Narcan® (Dupont
Pharm.), Generic; (Rx)
Naloxone HCl Neonatal Injection 0.02 mg/ml in 2 ml amps, & vials; Narcan® (Dupont Pharm);
Generic; (Rx)