Doses - NEOMYCIN SULFATE
Dogs: 
For treatment of hepatic encephalopathy: a) 22 mg/kg PO tid-qid (Hardy 1989)
b) For emergency treatment of hepatic encephalopathy secondary to portosystemic shunts:
Following evacuation enema instill 10 - 20 mg/kg neomycin sulfate diluted in water.
Oral neomycin not recommended. (Cornelius and Bjorling 1988)
c) 15 mg/kg as an enema every 6 hours after a cleansing enema or 10 - 20 mg/kg PO every6 hours. May be used with lactulose. (Johnson 1986)
For GI tract bacterial overgrowth:
a) 20 mg/kg PO bid-tid (Morgan 1988)
For systemic therapy (Caution: Very nephrotoxic):
a) 3.5 mg/kg IV, IM or SQ q8h (Kirk 1989)
Cats: 
For treatment of hepatic encephalopathy: a) Secondary to portosystemic shunts: 10 - 20 mg/kg PO bid. May be used in combination with lactulose or in cleansing enemas. (Center, Hornbuckle, and Scavelli 1986)
For systemic therapy (Caution: Very nephrotoxic):
a) 3.5 mg/kg IV, IM or SQ q8h (Kirk 1989)
Cattle: 
For oral administration to treat susceptible enteral infections: a) Cattle: 4 - 7.5 g/day PO divided 2-4 times daily at regular intervals. Calves: 2 - 3 g/day
PO divided 2-4 times daily at regular intervals. Doses are not standardized; use forgeneral guidance only. (Brander, Pugh, and Bywater 1982)
b) 10 - 20 mg/kg q12h (general guideline only). (Jenkins 1986)
c) 7-12 mg/kg PO q12h (Howard 1986)
d) Feed at levels of 70-140 g/ton of feed or mix the appropriate dose in the drinking waterwhich will be consumed by animals in 12 hours to provide 11 mg/kg or mix withreconstituted milk replacers to provide 200 - 400 mg/gallon. (Label directions; Neomix
Ag® 325¯Upjohn)
For respiratory tract infections:
a) 4.4 mg/kg IM q8-12h or 22 mg/kg IM q8-12h, : may give oral form IM or SQ. Athighest dose almost all P. hemolytica and P. multocida and 74% of C. pyogenes areinhibited. Nephrotoxicity and/or ototoxicity can occur even with low dose regimen.
Monitor creatinine levels. (Beech 1987b)
b) 6.6 - 19.8 mg/kg IM once daily. (Upson 1988)
Horses: 
For oral administration to treat susceptible enteral infections: a) Adults: 4 - 7.5 g/day PO divided 2-4 times daily at regular intervals. Foals: 2 - 3 g/day
PO divided 2-4 times daily at regular intervals. Doses are not standardized; use forgeneral guidance only. (Brander, Pugh, and Bywater 1982)
b) 5 - 15 mg/kg PO once daily (Robinson 1987)
For respiratory tract infections:
a) For pleuritis and less frequently pneumonia: 4.4 mg/kg IM or IV q8-12h.
Nephrotoxicity and/or ototoxicity can occur; nephrotoxicity more common in foals.
Local myositis seen with IM dosing particularly if treatment is longer than 7 days.
Systemic use of oral form is not approved, but is used with penicillin to increase gramnegative coverage (Beech 1987b)
Swine: 
For oral administration to treat susceptible enteral infections: a) Young pigs: 0.75 - 1 g/day PO divided 2-4 times daily at regular intervals. Doses arenot standardized; use for general guidance only. (Brander, Pugh, and Bywater 1982)
b) 7-12 mg/kg PO q12h (Howard 1986)
Sheep & Goats:
For oral administration to treat susceptible enteral infections: a) Lambs: 0.75 - 1 g/day PO divided 2-4 times daily at regular intervals. Doses are notstandardized; use for general guidance only. (Brander, Pugh, and Bywater 1982)
b) Feed at levels of 70-140 g/ton of feed or mix the appropriate dose in the drinking waterwhich will be consumed by animals in 12 hours to provide 11 mg/kg or mix withreconstituted milk replacers to provide 200 - 400 mg/gallon. (Label directions; Neomix
Ag® 325¯Upjohn)
Birds: 
For bacterial enteritis: a) Chickens, turkeys, ducks: Feed at levels of 70-140 g/ton of feed or mix the appropriatedose in the drinking water which will be consumed by animals in 12 hours to provide 11mg/kg. (Label directions; Neomix Ag® 325¯Upjohn)
Snakes:
For susceptible infections:
a) For bacterial gastritis: gentamicin 2.5 mg/kg IM every 72 hours with oral neomycin 15mg/kg plus oral live lactobacillus. (Burke 1986)
Monitoring Parameters -
For oral use:
For parenteral use: Refer to Amikacin monograph
Client Information - Clients should understand that the potential exists for severe toxicity(nephrotoxicity, ototoxicity) developing from this medication when used parenterally.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Neomycin Sulfate Oral Liquid 200 mg/ml
Biosol® (Upjohn); (OTC) Approved for use in cattle, swine, sheep, turkeys, laying hens, and broilers. Withdrawal times: Cattle = 30 days; Sheep and swine = 20 days, Turkeys and Layers = 14 days; Broilers = 5 days.
Also available as generically labeled products.
Neomycin Sulfate Oral Solution 50 mg/ml in 10 ml dropper bottles
Biosol Aquadrops® (Upjohn); (OTC) Approved for use in dogs and cats.
Neomycin Sulfate Oral Tablets 100 mg
Biosol® Tablets (Upjohn); (OTC) Approved for use in dogs and cats.
Neomycin Sulfate Intrauterine or Oral Boluses 500 mg; Biosol® Boluses (Upjohn); (OTC)
Approved for use in cattle, foals, swine, and sheep. Slaughter withdrawal times: Cattle = 30 days; Sheep and swine = 20 days. Milk withdrawal = 48 hours.
Neomycin Sulfate Soluble Powder 3.125 g/ounce;Biosol® Soluble Powder (Upjohn); (OTC)
Approved for use in dogs, cats, cattle, swine, sheep, and horses. Slaughter withdrawal times:
Cattle = 30 days; Sheep and swine = 20 days.
Neomycin Powder Water/Feed Additive 325 g/lb; Biosol 325® (Upjohn), Neomix Ag® 325 (Upjohn); (OTC) Approved for use in chickens, turkeys, ducks, nonlactating dairy cattle, beef cattle, goats, horses, mink, sheep, and swine. Slaughter withdrawal times: Cattle = 30 days;
Sheep and swine = 20 days, Turkeys & layers = 14 days; Broilers = 5 days.
There are several combination neomycin veterinary products, the following are examples:
Neomycin 25 mg, isopropamide 1.67 mg, prochlorperazine 3.33 mg capsules; Neomycin 75 mg, isopropamide 5 mg, prochlorperazine 10 mg capsules; Neo-Darbazine® #1 (Pfizer); (Rx)
Approved for use in dogs. Neo-Darbazine® #3 (SKB); (Rx) Approved for use in dogs.