Doses - NITROFURANTOIN

Dogs:

For susceptible bacterial urinary tract infections:
a) 4 mg/kg PO q6h (Osborne and Lulich 1987)
b) For recurrent UTI: Conventional dose: 4 mg/kg PO q8h; Prophylactic dose: 3-4 mg/kg
PO q24h (should be given at night after micturation and immediately before bedtime). (Polzin and Osborne 1985)
c) 4 mg/kg PO tid (Morgan 1988)

Cats:

For susceptible bacterial urinary tract infections:
a) 4 mg/kg PO q6h (Osborne and Lulich 1987)
b) For recurrent UTI: Conventional dose: 4 mg/kg PO q8h; Prophylactic dose: 3-4 mg/kg
PO q24h (should be given at night after micturation and immediately before bedtime). (Polzin and Osborne 1985)

Horses:

For susceptible urinary tract infections:
a) 2.5 - 4.5 mg/kg PO tid (Robinson 1987)
b) 10 mg/kg PO daily (Huber 1988a)
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects

3) Periodic liver function tests should be considered with chronic therapy
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Nitrofurantoin Macrocrystals Capsules 25 mg, 50 mg, and 100 mg; Macrodantin® (Procter &
Gamble Pharm); Macrobid® (Procter & Gamble Pharm); generic; (Rx)
Nitrofurantoin Oral Suspension 5 mg/ml in 60 ml and pint bottles; Furadantin® (Dura); (Rx)