Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - NITROPRUSSIDE SODIUM

Directions for preparation of infusion: Add 2 - 3 ml D5W to 50 mg vial to dissolve powder.
Add dissolved solution to 1000 ml of D5W and promptly protect solution from light (using aluminum foil or other opaque covering). Resultant solution contains 50 micrograms/ml of nitroprusside. Higher concentrations may be necessary in treating large animals. The administration setneed not be protected from light. Solution may have a slight brownish tint, but discard solutions thatturn to a blue, dark red or green color. Solution is stable for 24 hours after reconstitution. Do notadd any other medications to IV running nitroprusside.
Using a Mini-Drip IV set (for small animals) (60 drops ยป 1 ml; 1 drop contains approximately0.83 micrograms) and a flow control device (pump, controller, etc.). Dose to effect at a rate of 0.5 - 10 micrograms/kg/min IV constant infusion. A dose of 3 micrograms/kg/min will control mostpatients. Blood pressure must be continuously monitored. Avoid extravasation at IV site. (Plumb1988). A dosage of 1 - 10 micrograms/kg/min IV infusion is recommended for use in dogs by oneauthor (Moses 1988).
Monitoring Parameters -
  • 1) Blood pressure must be constantly monitored
  • 2) Acid/base balance
  • 3) Electrolytes (especially Na+)
    Client Information - Must only be used by professionals in a setting where precise IV infusionand constant blood pressure monitoring can be performed.
    Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

    Human-Approved Products:

    Nitroprusside Sodium Powder for Injection 50 mg/vial in 2ml & 5 ml vials; Nitropress®(Abbott); Generic; (Rx)
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