Doses - NOVOBIOCIN SODIUM

Dogs:

For susceptible infections:
a) 10 mg/kg q8h PO (Greene 1984)
For susceptible infections using the combination product (with tetracycline):
a) 22 mg/kg of each antibiotic PO q12h (Package insert; Albaplex®¯Upjohn)

Cattle:

For treatment of mastitis in dry cows:
a) Infuse contents of one syringe into each quarter at the time of drying off; not later than30 days prior to calving. (Package directions; Drygard® Suspension ¯Upjohn)
For treatment of mastitis in lactating cows:
a) Using the penicillin/novobiocin product (Special Formula 17900-Forte®): Infuse contents of one syringe in each infected quarter. Repeat once in 24 hours. (Package
Directions; Special Formula 17900-Forte®¯Upjohn)
Client Information: Shake mastitis tubes well before using.
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects3 Periodic liver function tests and CBC's are recommended if using long-term systemically.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Novobiocin (as the sodium) Oil Suspension 400 mg per 10 ml Mastitis tube; Drygard®
Suspension (Upjohn); (OTC) Approved for use in dry cows. Not to be used within 30 days ofcalving. Slaughter withdrawal = 30 days.
Novobiocin Premix 17.5 g/lb, and 25 g/lb; Albamix® Premix (Upjohn); (OTC) Approved foruse in chickens (not layers), turkeys (not layers for human consumption), ducks, and mink.
Slaughter withdrawal = chickens and turkeys (4 days), ducks (3 days), and mink (none).
Novobiocin Combination Products:
Novobiocin (as the sodium salt) 150 mg and Penicillin G Procaine 100, 000 IU per 10 ml
Mastitis Syringe; Special Formula 17900-Forte® (Upjohn); (OTC) Approved for use inlactating dairy cattle. Milk withdrawal = 72 hours. Slaughter withdrawal = 15 days.
Novobiocin Sodium 60 mg and Tetracycline HCl 60 mg tablets; Novobiocin Sodium 180 mgand Tetracycline HCl 180 mg tablets; Albaplex® and Albaplex® 3X (Upjohn); (Rx) Approvedfor use in dogs.
Novobiocin Sodium 60 mg, Tetracycline HCl 60 mg & Prednisolone 1.5 mg tablets; Novobiocin
Sodium 180 mg, Tetracycline HCl 180 mg & Prednisolone 4.5 mg tablets; Delta Albaplex®and Delta Albaplex® 3X (Upjohn); (Rx) Approved for use in dogs.

Human-Approved Products:

Novobiocin (as the sodium) 250 mg Capsules; Albamycin® (Upjohn); (Rx)