Doses - OMEPRAZOLE

Dogs:

For ulcer management:
a) 0.5 - 1 mg/kg PO once daily (Davenport 1992)
b) 20 mg (total dose) once daily (Papich 1992)
c) For severe ulceration unresponsive to H2 blockers; severe esophagitis unresponsive tometoclopramide and H2 blockers; gastrinoma (Zollinger-Ellison syndrome): 0.75 - 1mg/kg PO once daily (q24h) - or - one 20 mg capsule for animals > 20 kg, 10 mg (1/2capsule) for animals weighing >5 kg < 20 kg, 5 mg (1/4 capsule for animals weighing <5 kg. When using less than a full capsule, repackage granules in a gelatin capsule toavoid gastric acid degradation. (Johnson, Sherding et al. 1994)
d) 0.7 mg/kg (>20 kg, 20 mg/dog; <20 kg, 10 mg/dog) PO once daily (Matz 1995)
e) For dogs less than 20 kg: 0.7 mg/kg PO once a day; for dogs > 20 kg: 20 mg PO once aday (Johnson 1996)

Cats:

For ulcer management:
a) For cats: 0.7 mg/kg PO once a day (Johnson 1996)

Horses:

For ulcer management:
a) 0.7 - 1.4 mg/kg PO once daily. While dosage has not been firmly established, thesedosages have been shown to suppress gastric acid output for up to 24 hours. Useshould probably be limited to those cases where the client prefers once a day onlydosing. (Geor 1992)
Monitoring Parameters - 1) Efficacy; 2) Adverse Effects
Client Information - Brief client on drug's cost before prescribing. Give before meals, preferablyin the morning.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Omeprazole Oral Sustained Release 10 mg & 20 mg Capsules; Prilosec® (Losec® in Canada);(Astra Merck); (Rx)