Doses - OXACILLIN SODIUM

Dogs:

For susceptible infections:
a) 22 - 40 mg/kg PO q8h (Vaden and Papich 1995)
b) 5.5 - 11 mg/kg IV q8h; 27.5 - 33 mg/kg PO q8h (Aronson and Aucoin 1989)
c) For Staph. infections: 10 - 20 mg/kg PO, IV, or IM qid (Morgan 1988)
d) For penicillinase-producing Staph. endocarditis: 50 - 60 mg/kg tid for 4-6 weeks (routenot indicated). (Sisson and Thomas 1986)
e) For canine pyoderma: 22 mg/kg PO q8h (Ihrke 1986)
f) For systemic therapy for Staph. blepharitis: 22 mg/kg PO tid (Laratta 1986)
g) 7 mg/kg IM q8h; 8 -15 mg/kg PO q8h (Ford and Aronson 1985)
h) 10 - 22 mg/kg q6-8h PO; 7 - 25 mg/kg IV or IM q4-6h (Greene 1984)

Cats:

For susceptible infections:
a) 22 - 40 mg/kg PO q8h (Vaden and Papich 1995)
b) 5.5 - 11 mg/kg IV q8h; 27.5 - 33 mg/kg PO q8h (Aronson and Aucoin 1989)
c) For Staph. infections: 10 - 20 mg/kg PO, IV, or IM qid (Morgan 1988)
d) 7 mg/kg IM q8h; 8 -15 mg/kg PO q8h (Ford and Aronson 1985)
e) 10 - 22 mg/kg q6-8h PO; 7 - 25 mg/kg IV or IM q4-6h (Greene 1984)

Horses:

For susceptible infections:
a) Foals: 20 - 30 mg/kg IV q6-8h (Dose extrapolated from adult horse data; use lowerdose or longer interval in premature foals or those less than 7 days old.) (Caprile and Short 1987)
b) 25 - 50 mg/kg IM, IV bid (Robinson 1987)
Client Information - Unless otherwise instructed by the veterinarian, this drug should be given onan empty stomach, at least 1 hour before feeding or 2 hours after. Keep oral solution in the refrigerator and discard any unused suspension after 14 days.
Dosage Forms/Preparations/FDA Approval Status - Veterinary-Approved Products: None

Human-Approved Products:

Oxacillin Sodium Capsules 250 mg, 500 mg; Prostaphlin® (Apothecon) (Rx), Bactocill®(Beecham); (Rx); generic, (Rx)
Oxacillin Sodium Powder for Oral Solution 250 mg/5 ml in 100 ml bottles; Prostaphlin®(Apothecon); (Rx)
Oxacillin Sodium Powder for Injection 250 mg vials, 500 mg vials, 1 g, 2 g, & 4 g vials; 1 g & 2g piggyback vials, 4 g and 10 g bulk vials; Prostaphlin® (Apothecon) (Rx); Bactocill® (S-K
Beecham); (Rx); Oxacillin Sodium® (Apothecon) (Rx)