Doses - OXYTETRACYCLINE, OXYTETRACYCLINE HCL
Dogs: 
For susceptible infections: a) 20 mg/kg PO tid (Morgan 1988)
b) 10 mg/kg IV initially, then 7.5 mg/kg IV maintenance q12h (Ford and Aronson 1985)
c) 20 mg/kg PO q8-12h; (may give with food if GI upset occurs; avoid or reduce dose inanimals with renal or severe liver failure; avoid in young, pregnant or breeding animals)(Vaden and Papich 1995)
d) 55 - 82.5 mg/kg PO q8h (Aronson and Aucoin 1989)
e) 20 mg/kg PO q8h or 7 mg/kg IV or IM q12h. (Kirk 1989)
f) For haemobartonellosis: 22 mg/kg PO tid for 3 weeks (Lissman 1988)
Cats: 
For susceptible infections: a) 20 mg/kg PO tid (Morgan 1988)
b) 10 mg/kg IV initially, then 7.5 mg/kg IV maintenance q12h (Ford and Aronson 1985)
c) 20 mg/kg PO q8-12h; (may give with food if GI upset occurs; avoid or reduce dose inanimals with renal or severe liver failure; avoid in young, pregnant or breeding animals) (Vaden and Papich 1995)
d) 55 - 82.5 mg/kg PO q8h (Aronson and Aucoin 1989)
e) 20 mg/kg PO q8h or 7 mg/kg IV or IM q12h. (Kirk 1989)
f) For haemobartonellosis: 16 - 20 mg/kg PO tid for 3 weeks (Lissman 1988)
Cattle: 
For susceptible infections: a) 5 - 10 mg/kg IM q24h or 20 mg/kg q48-72h IM if depot form (LA®-200);2.5 - 5 mg/kg IV q24h;10 - 20 mg/kg PO q12h. (Jenkins 1986)
b) For respiratory tract infections: Using 50 mg/ml product: 11 mg/kg IM or SQ q24h or IV q12-24h.
Using 100 mg/ml product: 20 mg/kg IM q24h
Using 200 mg/ml product (LA-200®): 20 mg/kg IM q3-4 days. IM or SQ doses should be injected into the neck and not more than 10 ml per site. IMroute may lead to myositis and abscesses. Rapid IV injection may cause collapse.
Phlebitis possible with IV dosing. (Beech 1987b)
c) For anthrax: 4.4 mg/kg IM or IV daily; do not use in healthy animals recently vaccinated against anthrax as the protective effect of the vaccine may be negated. (Kaufmann1986)
d) For bovine anaplasmosis:
For control: At start of vector season give 6.6 - 11 mg/kg (if using 50 mg/ml or 100mg/ml product) or 20 mg/kg (if using depot form ¯LA®-200) every 21-28 days andextending 1-2 months after vector season ends.
To eliminate carrier state: If using 50 mg/ml or 100 mg/ml product: 22 mg/kg IM (notover 10 ml per injection site) or IV (diluted in saline) daily for 5 days; or 11 mg/kg asabove for 10 days. If using depot form (LA®-200): Give 20 mg/kg for 4 treatmentsdeep IM in two separate injection sites at 3 day intervals.
For treatment of sick animals: Preferably using depot form (LA®-200): Give 20 mg/kgone time.
For temporary/prolonged protection for rest of herd: If using 50 mg/ml or 100 mg/mlproduct: 6.6 - 11 mg/kg IM (not over 10 ml per injection site) repeat at 21-28 day intervals throughout vector season for prolonged protection. If using depot form (LA®-200): Give 20 mg/kg IM as above and repeat at 28 day intervals for prolonged protection. (Richey 1986)
e) For pneumonia: If using 50 mg/ml or 100 mg/ml product: 11 mg/kg SQ once daily. Ifusing depot form (LA®-200): Give 20 mg/kg IM q48h. (Hjerpe 1986)
f) 6 - 11 mg/kg IM or IV; 10 - 20 mg/kg PO q6h (Howard 1986)
g) If using 50 mg/ml or 100 mg/ml product: 10 mg/kg IM initially, then 7.5 mg/kg IMonce daily. If using depot form (LA®-200): Give 20 mg/kg IM q48h. (Baggot 1983)
h) 22 - 33 mg/kg once daily IM or IV.
If using LA-200®: 39.6 mg/kg IM q48h (Upson 1988)
Horses: 
For susceptible infections: a) 5 - 10 mg/kg IV bid (Robinson 1987)
b) For respiratory tract infections: 5 mg/kg IV q12h; do not give too rapidly. (Beech 1987b)
c) 3 mg/kg IV q12h (Baggot and Prescott 1987)
d) 5 - 11 mg/kg IV q12h (Upson 1988)
Swine: 
For susceptible infections: a) For anthrax: 4.4 mg/kg IM or IV daily; do not use in healthy animals recently vaccinated against anthrax as the protective effect of the vaccine may be negated. (Kaufmann 1986)
b) 6 - 11 mg/kg IV or IM; 10 - 20 mg/kg PO q6h (Howard 1986)
c) If using 50 mg/ml or 100 mg/ml product: 10 mg/kg IM initially, then 7.5 mg/kg IMonce daily. (Baggot 1983)
Sheep & Goats:
For susceptible infections: a) For anthrax: 4.4 mg/kg IM or IV daily; do not use in healthy animals recently vaccinated against anthrax as the protective effect of the vaccine may be negated. (Kaufmann1986)
b) 6 - 11 mg/kg IV or IM; 10 - 20 mg/kg PO q6h (Howard 1986)
Birds: 
For chlamydiosis (Psittacosis): a) Using 200 mg/ml product (LA-200®): 50 mg/kg IM once every 3-5 days in birds suspected or confirmed of having disease. Used in conjunction with other forms of tetracyclines. IM injections may cause severe local tissue reactions. (McDonald 1989)
b) Using 200 mg/ml product (LA-200®): 200 mg/kg IM once daily for 3-5 days. Hasworked well in treating breeding birds to control outbreak and while getting birds to eatoral forms doxycycline or chlortetracycline. (Clubb 1986)
Reptiles: 
For susceptible infections: a) For turtles and tortoises: 10 mg/kg PO once daily for 7 days (useful in ulcerativestomatitis caused by Vibrio) (Gauvin 1993)
Monitoring Parameters -
Client Information - Avoid giving this drug orally within 1-2 hours of feeding, giving milk ordairy products.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Oxytetracycline HCl 50 mg/ml, 100 mg/ml Injection. There are many approved oxytetracyclineproducts marketed in these concentrations. Some are labeled for Rx (legend) use only, whilesome are over-the-counter (OTC). Depending on the actual product, this drug may beapproved for use in swine, non-lactating dairy cattle, beef cattle, chickens or turkeys. Productsmay also be labeled for IV, IM, or SQ use. Withdrawal times vary with regard to individualproducts. Slaughter withdrawal times vary in cat le from 15-22 days, swine 20-26 days, and 5days for chickens and turkeys. Refer to the actual labeled information for the product used formore information. Some trade names for these products include: Terramycin®, Liquamycin®,
Biomycin (Bio-Ceutic), Medamycin® (TechAmerica), Biocyl® (Anthony), Oxyject® (Fermenta), and Oxytet® (BI).
Oxytetracycline base 200 mg/ml Injection in 100, 250, and 500 ml bottles; Liquamycin® LA-200® (Pfizer); (OTC or Rx) Approved for use in swine, non-lactating dairy cattle and beef cattle. Slaughter withdrawal = 28 days for swine and cattle.
Oxytetracycline Oral Tablets (Boluses) 250 mg tablet; Terramycin® Scours Tablets (Pfizer);(OTC) Approved for use in non-lactating dairy and beef cattle. Slaughter withdrawal = 7 days.
Oxytetracycline is also available in feed additive, premix, ophthalmic and intramammaryproducts.
Established residue tolerances: Uncooked edible tissues of swine, cattle, salmonids, catfish andlobsters: 0.10 ppm. Uncooked kidneys of chickens or turkeys: 3 ppm. Uncooked muscle, liver, fat or skin of chickens or turkeys: 1 ppm.
Human-Approved Products:
Oxytetracycline Oral Capsules 250 mg; Terramycin® (Pfizer); Uri-Tet® (AmericanUrologicals); generic; (Rx)
Oxytetracycline For Injection (IM only) 50 mg/ml or 125 mg/ml (both with 2% lidocaine) in 2ml amps and 10 ml vials; Terramycin® I.M. (Roerig); generic, (Rx)