Doses - PENICILLIN V POTASSIUM

Dogs:

For analgesia:
a) Initially 1.65 mg/kg; up to 3.3 mg/kg IM. Duration of effect generally lasts 3 hours. Ifdose is repeated, use different injection site. (Package Insert; Talwin®-V - Winthrop)
b) 0.2 - 0.5 mg/kg IM prn (Morgan 1988)
c) 0.5 - 1.0 mg/kg IM (Kirk 1986)
Cats: Note: Pentazocine tends to cause dysphoria in cats. Alternative analgesics are recommended.
For analgesia:2.2 - 3.3 mg/kg SQ, IM or IV (Booth 1988a)

Horses:

For analgesia:
a) 0.33 mg/kg slowly in jugular vein. In cases of severe pain, a second dose (0.33 mg/kg)be given IM 15 minutes later (Package Insert; Talwin®-V - Winthrop)
b) 0.33 - 0.66 mg/kg IV, IM or SQ (Jenkins 1987)
c) 0.4 - 0.8 mg/kg IV (Muir 1987)
d) 0.4 - 0.9 mg/kg IV (Thurmon and Benson 1987)
Note: Duration of analgesia may last only 10-30 minutes following an IV dose.

Swine:

Analgesia:
a) 2.0 mg/kg IM q4h prn (Jenkins 1987)
Monitoring Parameters -

1) Analgesic efficacy

2) Respiratory rate/depth

3) Appetite/bowel function

4) CNS effects
Client Information - Clients should report any significant changes in behavior, appetite, bowel orurinary function in their animals. It is not approved for use in food producing animals (including horses to be used for food). Alpentazocine products are Class-IV controlled substances.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Pentazocine Lactate Injection: 30 mg/ml (as base) in 10 ml vials; Talwin®-V (Pharmacia &
Upjohn); (Rx) Pentazocine lactate injection is approved for use in horses and dogs.

Human-Approved Products:

Pentazocine Lactate Injection: 30 mg/ml in 10 ml vials and 1, 1.5, & 2 ml amps and pre-filled 2ml carpuject syringes; Talwin ® (Sanofi Winthrop) (Rx)
Pentazocine HCl 50 mg & Naloxone HCl 0.5 mg Tablets (Scored); Talwin NX® (Sanofi
Winthrop); Pentazocine & Naloxone HCl® (Royce) (Rx)
Pentazocine HCl 12.5 mg & Aspirin 325 mg Tablets; Talwin Compound Caplets® (Sanofi
Winthrop) (Rx)
Pentazocine HCl 25 mg & Acetominophen 650 mg Tablets; Talacen Caplets® (Sanofi
Winthrop) (Rx)
Note: All pentazocine products are Class-IV controlled substances and are prescription items only.