Doses - PHENYLBUTAZONE

Dogs:

a) 14 mg/kg PO tid initially (maximum of 800 mg/day regardless of weight), titrate dose tolowest effective dose (Package Insert; Butazolidin® - Coopers)
b) For analgesia/phlebitis: 3-5 mg/kg PO tid; for analgesia/spinal disorders: 8-10 mg/kg
PO tid (max. 800 mg/day); for antiinflammation/arthritis: 13 mg/kg PO tid for 48 hrs, then taper dose to lowest effective dose (max. of 800 mg/day). (Morgan 1988)

Cattle:

a) 4 mg/kg IV or orally q24h (Koritz 1986)
b) 4 - 8 mg/kg PO or 2 - 5 mg/kg IV (Howard 1986)
c) 10 - 20 mg/kg PO, then 2.5 - 5.0 mg/kg q24h or 10 mg/kg every 48 hours PO (Jenkins1987)

Horses:

a) 4.4 - 8.8 mg/kg q24hrs PO or 3-6 mg/kg q12h IV (Do not exceed 8.8 mg/kg/day(Jenkins 1987)
b) 1 - 2 grams IV per 454 kg (1000 lb.) horse. Injection should be made slowly and withcare. Limit IV administration to no more than 5 successive days of therapy. Follow withoral forms if necessary; or 2 - 4 grams PO per 454kg (1000 lb.) horse. Do not exceed 4grams/day. Use high end of dosage range initially, then titrate to lowest effective dose.(Package Insert; Butazolidin® - Coopers)
c) 4.4 mg/kg PO twice on the first day, then 2.2 mg/kg PO bid for 4 days, then 2.2 mg/kg
PO once daily or every other day. (Taylor et al. 1983)

Swine:

a) 4 mg/kg IV or orally q24h (Koritz 1986)
b) 4 - 8 mg/kg PO or 2 - 5 mg/kg IV (Howard 1986)
Monitoring Parameters - 1) Analgesic/anti-inflammatory/antipyrexic effect 2) Regular completeblood counts with chronic therapy (especially in dogs). The manufacturer recommends weekly
CBC's early in therapy, and biweekly with chronic therapy 3) Urinalysis &/or renal functionparameters (serum creatinine/BUN) with chronic therapy 4) Plasma protein determinations, especially in ponies, foals, and debilitated animals.
Client Information/FDA Approval Status - Do not administer injectable preparation IM or SQ.
Approved for use in dogs and horses not intended for food. While phenylbutazone is not approved for use in cattle, it is used. A general guideline for meat withdrawal times are: one dose=30days, 2 doses=35 days, and 3 doses=40 days. Phenylbutazone is a veterinary prescription drug.
Dosage Forms/Preparations (Veterinary) -
Phenylbutazone Tablets 100 mg, 400 mg, 1 gram tablets; 2 gram boluses, 4 gram boluses ;
Butazolidin® (Schering); also available generically
Phenylbutazone Paste Oral syringes containing 6 grams or 12 grams/syringe; Butazolidin®
Paste (Schering); Phenylzone® Paste (Luitpold)
Phenylbutazone Oral Gel: Each 30 grams of gel contains 4 grams phenylbutazone, 30 grams (ofgel) per syringe; Butatron® (Rhone Merieux)
Phenylbutazone Micro-encapsulated powder; Equipalazone® (Steri-Vet); 1 gm packets, 60'sPhenylbutazone Injection 200 mg/ml; 100 ml vials; Butazolidin® (Schering); generic