Doses - PROPANTHELINE BROMIDE

Dogs:

a) For small dogs: 7.5 mg PO q8h
For medium dogs: 15 mg PO q8h
For large dogs: 30 mg PO q8h (Kirk 1986)
For detrusor hyperreflexia, urge incontinence:
a) 0.2 mg/kg PO q6-8h; increase dose if necessary to the lowest dose which will controlsymptoms (Polzin and Osborne 1985)
b) 7.5 - 30 mg PO once a day to tid, start low and increase until symptoms abated or sideeffects occur (Labato 1988)
c) 5 - 30 mg PO tid (Chew, DiBartola, and Fenner 1986)
For sinus bradycardia, incomplete AV block, etc.:
a) If injectable anticholinergic therapy is shown to be effective and desire to convert to oraltherapy: 0.5 - 1.0 mg/kg PO tid (Moses 1988)
For colitis, irritable bowel syndrome, etc.
a) 0.25 mg/kg PO tid; do not use longer than 48-72 hours (48 hours for acute colitis)(DeNovo 1988)
b) 0.5 mg/kg bid-tid (Chiapella 1986)
As an antiemetic/antidiarrheal:
a) 0.25 mg/kg PO q8h (DeNovo 1986)

Cats:

a) 7.5 mg PO q8h (Kirk 1986)
For detrusor hyperreflexia, urge incontinence:
a) 7.5 mg PO every 3rd day; increase dose if necessary to the lowest dose which willcontrol symptoms (Polzin and Osborne 1985)
b) 7.5 mg PO every 24 to 72 hours, start low and increase until symptoms are abated orside effects occur (Labato 1988)
c) 5 - 7.5 mg PO tid (Chew, DiBartola, and Fenner 1986)
For sinus bradycardia, incomplete AV block, etc.:
a) Although generally ineffective, a trial may be attempted using: 0.8 - 1.6 mg/kg tid(Harpster 1986)
For chronic colitis
a) 0.5 mg/kg bid-tid (Chiapella 1986)
As an antiemetic/antidiarrheal:
a) 0.25 mg/kg PO q8h (DeNovo 1986)

Horses:

a) 0.014 mg/kg IV (Robinson 1987)
b) 30 mg IV to inhibit peristalsis for 2 hours during rectal surgery (Merkt et al. 1979)
Note: There is no commercially available injectable product available in the U.S.A..
Should a preparation be made from oral tablets, it should be freshly prepared and filtered through a 0.22 micron filter before administering. Use with caution.
Monitoring Parameters - Dependent of reason for use

1) Clinical efficacy

2) Heart rate and rhythm if indicated

3) Adverse effects
Client Information - Dry mouth may be relieved by applying small amounts of water to animal'stongue for 10-15 minutes. Protracted vomiting and diarrhea can be serious; contact veterinarian ifsymptoms are not alleviated.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None