Doses - PROPRANOLOL HCL

Dogs:

a) IV: 0.02 - 0.06 mg/kg IV slowly; PO: 0.2 - 1.0 mg/kg tid. (Murtaugh and Ross 1988)
b) IV: 0.04 - 0.06 mg/kg IV slowly; PO:0.2 - 1.0 mg/kg q8h. (Miller 1985)
c) For ventricular hypertrophy from aortic stenosis: 0.125 - 0.25 mg/kg PO bid
For ventricular arrhythmias: 0.02 - 0.06 mg/kg IV over 2-3 minutes or 0.2 mg/kg POtid; maximum 1 mg/kg/day.
For hypertrophic cardiomyopathy: 0.3 - 1.0 mg/kg PO tid; maximum of 120 mg/day.
For hypertension: 2.5 - 10 mg PO bid-tid
For arrhythmias secondary to pheochromocytomas: 0.15 - 0.5 mg/kg PO tid or 0.03 - 0.10 mg/kg IV (Morgan 1988)
d) For susceptible cardiac arrhythmias: General: 0.44 - 1.1 mg/kg q8h. Small dogs: 2.5 - 20 mg PO q8-12h (Note: actual reference has this dose per pound, but it is believedthis is an error); Medium and large dogs: 10 - 40 mg PO q8-12h; Large and giantbreeds: 40 - 80 mg PO q8-12h.
Intravenously: 0.25 - 0.5 mg IV no more frequently than every 1-3 minutes. (Ettinger 1989)

Cats:

a) 2.5 - 5.0 mg bid to tid (Murtaugh and Ross 1988)
b) IV: 0.04 mg/kg IV slowly; PO: 2.5 - 5.0 mg PO q8-12h (Miller 1985)
c) For hypertrophic cardiomyopathy: Cats 4.5 kg or less: 2.5 mg PO bid- tid; Cats 5 kg ormore: 5 mg PO bid-tid
For hypertension: 2.5 - 5.0 mg PO bid- tid (Morgan 1988)
d) For adjunctive therapy (to control tachycardia) in feline hyperthyroidism: 2.5 mg POq8-12h; adjust dose as necessary. (Meric 1989)
e) For suceptible cardiac arrhythmias: 2.5 mg PO q12-24h; 0.25 - 0.5 mg IV no morefrequently than every 1-3 minutes. (Ettinger 1989)

Horses:

a) 0.1 - 0.3 mg/kg twice a day IV administered over 1 minute (Muir and McGuirk 1987a)
b) Oral: Days 1 & 2: 175 mg tid; Days 3 & 4: 275 mg tid; Days 5 & 6: 350 mg tid.
Intravenous: Days 1 & 2: 25 mg bid; Days 3 & 4: 50 mg bid; Days 5 & 6: 75 mg bid(Hilwig 1987)
Monitoring Parameters -

1) ECG

2) Toxicity (see Adverse Effects/Overdosage)

3) Blood pressure if administering IV
Client Information - To be effective, the animal must receive all doses as prescribed. Notifyveterinarian if animal becomes lethargic or becomes exercise intolerant, begins wheezing, hasshortness of breath or cough, or develops a change in behavior or attitude.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Propranolol HCl Tablets 10 mg, 20 mg, 40 mg, 60 mg, 80 mg, 90 mg; Inderal® (Wyeth-Ayerst),
Generic; (Rx)
Propranolol HCl Extended/Sustained-Release capsules 60 mg, 80 mg, 120 mg, 160 mg;
Inderal® LA (Wyeth-Ayerst); Betachron E-R® (Inwood); generic, (Rx)
Propranolol for Injection 1 mg/ml in 1 ml amps or vials; Inderal® (Wyeth-Ayerst) (Rx),
Generic; (Rx)
Propranolol Oral Solution 4 mg/ml, 8 mg/ml, 80 mg/ml concentrate in 30 ml; Propranolol
Intensol® (Roxane); Propranolol HCl® (Roxane) (Rx)
Also, fixed dose combination products containing propranolol and hydrochlorothiazide are availableto treat hypertension in humans.
Prostaglandin F2 alpha - see Dinoprost