Doses - SODIUM IODIDE

Cattle & Sheep & Goats:

For treatment of actinobacillosis (woody tongue):
a) 70 mg/kg IV given as a 10% or 20% solution; repeat at least one more time at a 7-10day interval. Refractory cases may require more frequent (2-3 day intervals) treatment.
Severe, generalized, or refractory cases may require adjunctive tx with antibiotics (sulfas, aminoglycoside or tetracyclines). (Smith 1996a)
For treatment of actinomycosis (lumpy jaw):
a) 70 mg/kg IV given as a 10% or 20% solution at 7-10 day intervals or more frequentlyuntil signs of iodism occur (see Overdose above). Also requires adjunctive tx withantibiotics: isoniazid (10 mg/kg/day PO for one month), penicillin (10, 000 U/kg bid)and an aminoglycoside where treating a valuable animal or twice daily dosing for 7-14days is possible. (Smith 1996b)
For treatment of actinobacillosis or actinomycosis in sheep:
a) 20 ml of a 10% solution subQ; repeated weekly for 4-5 weeks (Howard 1986)

Horses:

For treatment of sporotrichosis:
a) Sodium iodide 20 - 40 mg/kg orally daily for several weeks (Fadok 1992)
Monitoring Parameters/Client Information - Ruminants: 1) Clinical efficacy 2) Signs ofiodism (excessive tearing, nasal discharge, scaly haircoats/dandruff, hyperthermia, decreased milkproduction and weight gain, coughing, inappetence, and diarrhea). Although formal withholdingtimes were not located, there is concern about using this product in animals about to be slaughtered.
In the interest of public health, author recommends not using within 30 days of slaughter.
Dosage Forms/Preparations/FDA Approval Status - Veterinary-Approved Products:
Sodium Iodide Injection 20 g/100 ml (20%; 200 mg/ml) in 250 ml vials¯available as multior single use vials; Generic; (Rx)
Human-Approved Products: NOTE: The following are listed for information purposes.
The above monograph pertains to the veterinary injectable product only.
Sodium Iodide123 Oral Capsules 3.7 mBq and 7.4 mBq (Note: Radioactive isotope usedfor thyroid diagnostic procedures) (Mallinckrodt); (Rx)
Sodium Iodide131 Capsules and Oral solution (Note: Radioactive isotope used for treatment of hyperthyroidism and thyroid carcinoma; requires NRC approval for use);(Bracco, Mallinckrodt); (Rx)
Sodium Phosphate - see Phosphate, Sodium