Doses - TETRACYCLINE HCL

Dogs:

For susceptible infections:
a) For UTI: 55 mg/kg/day divided into 3 daily dosages PO (Rogers and Lees 1989)
b) 20 mg/kg PO q8h; 7 mg/kg IV or IM q12h (Kirk 1989)
c) 20 mg/kg PO q8-12h; (may give with food if GI upset occurs; avoid or reduce dose inanimals with renal or severe liver failure; avoid in young, pregnant or breeding animals)(Vaden and Papich 1995)
d) 22 - 33 mg/kg PO q8h (Aronson and Aucoin 1989)
e) For Lyme Disease: 22 mg/kg PO tid (Lissman 1986)
d) For acute colitis: 22 mg/kg PO tid (Morgan 1988)
e) For brucellosis: 10 - 20 mg/kg PO tid for 28 days (Morgan 1988)
f) For Yersinia pestis infections: 15 mg/kg PO tid (Morgan 1988)
g) For mastitis: 10 mg/kg PO tid for 21 days (Morgan 1988)
h) For Rocky Mountain Spotted Fever/ehrlichiosis: 22 mg/kg PO tid for 2 weeks. (Greene1986)
i) For rickettsial diseases:
Ehrlichiosis: 22 mg/kg PO tid for at least 14 days
Salmon Poisoning: 22 mg/kg PO tid for 10-14 days or 7 mg/kg IV tid
Rocky Mountain Spotted Fever: 22 mg/kg PO tid for 10-14 days (Lissman 1988)
j) For canine ehrlichiosis: 22 mg/kg every 8 hours for 2-3 months (duration of treatmentbased upon preliminary data). For prophylaxis in endemic areas: 6 mg/kg once daily.(Greene 1995)
k) For Rocky Mountain Spotted Fever: 22 mg/kg q8h for 14-21 days (Sellon and Breitschwerdt 1995)
For facial tear staining:
a) 5 - 10 mg/kg/day or 50 mg per dog per day. Results are variable. (Kern 1986)
For pleurodesis:
a) Using capsules or aqueous solution; mix 20 mg/kg in 4 ml per kg of saline and infuseinto pleural space. (Morgan 1988)

Cats:

For susceptible infections:
a) 20 mg/kg PO q8h; 7 mg/kg IV or IM q12h (Kirk 1989)
b) For rickettsial diseases: 16 mg/kg PO tid for 21 days (Morgan 1988)
c) 20 mg/kg PO q8-12h; (may give with food if GI upset occurs; avoid or reduce dose inanimals with renal or severe liver failure; avoid in young, pregnant or breeding animals)(Vaden and Papich 1995)
d) 22 - 33 mg/kg PO q8h (Aronson and Aucoin 1989)

Cattle:

For susceptible infections in calves:
a) 11 mg/kg orally (Howard 1986)
b) 11 mg/kg PO bid for up to 5 days (Label directions; Polyotic®¯American Cyanamid)

Sheep:

For susceptible infections:
a) 11 mg/kg PO bid for up to 5 days (Label directions; Polyotic®¯American Cyanamid)

Horses:

For susceptible infections:
a) 5 - 7.5 mg/kg IV q12h (Brumbaugh 1987)

Swine:

For susceptible infections:
a) 22 mg/kg PO for 3 to 5 days in drinking water (Label directions; Polyotic®¯American
Cyanamid)

Birds:

For susceptible infections:
a) For treatment of psittacossis in conjunction with LA-200® (see oxytetracycline doses)and/or medicated pellets and/or Keet Life: Using 25 mg/ml oral suspension, mix 2teaspoonsful to 1 cup of soft food.
For mild respiratory disease (especially flock treatment): Mix 1 teaspoonful of 10 g/6.4oz. soluble powder per gallon of drinking water. Used as an adjunct for psittacossiswith other tetracycline forms. Will not reach therapeutic levels by itself. Prepare freshsolution twice daily as potency is rapidly lost. (McDonald 1989)
b) Mix 1 teaspoonful of 10 g/6.4 oz. soluble powder per gallon of drinking water andadminister for 5-10 days. Prepare fresh solution 2-3 times daily as potency is rapidlylost.
For converting regimen to pelleted feeds administer oral suspension by gavage at 200 - 250 mg/kg once or twice daily until feeds are accepted. Is not adequate therapy for longterm chlamydiosis (psittacosis) treatment. (Clubb 1986)
Monitoring Parameters -

1) Adverse effects

2) Clinical efficacy

3) Long-term use or in susceptible patients: periodic renal, hepatic, hematologic evaluations
Client Information - Avoid giving this drug orally within 1-2 hours of feeding, giving milk ordairy products. If gastrointestinal upset occurs, giving with a small amount of food may help, butthis will also reduce the amount drug absorbed.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times -
Veterinary -Approved Products:
Tetracycline Oral Suspension 100 mg/ml (approximately 5 mg/drop) in 15 ml and 30 ml bottles
Panmycin Aquadrops® (Upjohn); (Rx) Approved for use in dogs and cats.
Tetracycline HCl Oral Boluses 500 mg
Polyotic® Oblets® (American Cyanimid) (Rx) Approved for use in calves and sheep.
Slaughter withdrawal = 12 days calves; = 5 days sheep.
Panmycin® Oral Boluses (Upjohn); (OTC) Approved for use in calves. Slaughter withdrawal = 12 days.
Tetracycline HCl Soluble Powder as a water additive
Polyotic Soluble Powder® (10 g or 25 g tetracycline HCl/lb); (OTC)
Polyotic Soluble Powder Concentrate® (102.4 g tetracycline HCl/lb); (OTC) Both areapproved for use in calves, and swine. Slaughter withdrawal = 4 days calves; = 7 daysswine
Tetracycline HCl Soluble Powder-324® (324 g tetracycline HCl/lb); (OTC) Approved foruse in calves, swine, chickens, and turkeys. Slaughter withdrawal = 4 days swine, chickens, and turkeys; = 5 days calves

Human-Approved Products:

Tetracycline HCl Oral Capsules: 100 mg (capsules only from Richlyn Labs), 250 mg, 500 mg;
Many trade names, including: Achromycin-V® (Lederle), Sumycin '250'® & 500 (Apothecon);
Panmycin® (Upjohn), generic; (Rx)
Tetracycline HCl Tablets: 500 mg; Tetracycline® (Dr's Pharm); Sumycin 500® (Apothecon)(Rx)
Tetracycline HCl Oral Suspension 25 mg/ml in 60, 473, & 480 ml; Achromycin-V® (Lederle)(Rx), Sumycin Syrup® (Apothecon);Tetralan Syrup® (Lannett); generic; (Rx)
Tetracycline HCl Fiber: 12.7 mg/23 cm Actisite® (Alza) (Rx)Tetracycline HCl Topical solution: 2.2 mg/ml Topicycline® (Roberts) (Rx)
Theophylline - see Aminophylline