Doses - THIAMINE HCL

Dogs:

For thiamine deficiency:
a) 5 - 50 mg IM, SQ, or IV (depending on formulation) (Phillips 1988b)
b) 1 - 2 mg IM (Greene and Braund 1989)
c) 2 mg/kg PO once daily (Davis 1985)
d) 100 - 250 mg SQ bid for several days until regression of symptoms with complete recovery. (Hoskins 1988)
For ethylene glycol toxicity:
a) 100 mg/day PO (Morgan 1988)

Cats:

For thiamine deficiency:
a) 100 - 250 mg parenterally twice a day (experimentally, as little as 1 mg is effective).(Armstrong and Hand 1989)
b) 1 - 2 mg IM (Greene and Braund 1989)
c) 4 mg/kg PO once daily (Davis 1985)
d) 100 - 250 mg SQ bid for several days until regression of symptoms with complete recovery. (Hoskins 1988)
e) 10 - 20 mg/kg IM or SQ bid-tid until signs abate, then 10 mg/kg PO once daily for 21days. (Morgan 1988)

Cattle:

For thiamine deficiency:
a) For polioencephalomalacia: Initially, 10 mg/kg IV, then 10 mg/kg IM bid for 2-3 days.
If no improvement within 4 days, may be advisable to recommend slaughter. (Dill 1986)
b) Calves: 5 - 50 mg; Ox: 200 - 1000 mg IM, SQ, or IV (depending on formulation). (Phillips 1988b)
For adjunctive therapy of lead poisoning:
a) 2 mg/kg IM (at same time as CaEDTA therapy); total daily dose 8 mg/kg. (Brattan and Kowalczyk 1989)

Horses:

For thiamine deficiency:
a) 0.5 - 5 mg/kg IV, IM or PO (Robinson 1987)
b) 100 - 1000 mg IM, SQ, or IV (depending on formulation). (Phillips 1988b)

Swine:

For thiamine deficiency:
a) 5 - 100 mg IM, SQ, or IV (depending on formulation). (Phillips 1988b)

Sheep & Goats:

For thiamine deficiency:
a) For polioencephalomalacia: Initially, 10 mg/kg IV, then 10 mg/kg IM bid for 2-3 days.
If no improvement within 4 days, may be advisable to recommend slaughter. (Dill 1986)
b) Sheep: 20 - 200 mg IM, SQ, or IV (depending on formulation). (Phillips 1988b)
Monitoring Parameters -
1) Efficacy
Client Information - Epidemiologic investigation as to the cause of thiamine deficiency (diet, plants, raw fish, etc.) should be performed with necessary changes made to prevent recurrence.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Thiamine HCl for Injection 200 mg/ml and 500 mg/ml in 30 and 100 ml vials
Available generically labeled; (Rx) Labeled for use in small and large animals. Approval statusis uncertain.
There are several B-complex vitamin preparations available that may also have thiamine included.

Human-Approved Products:

Thiamine Oral Tablets 50 mg, 100 mg, 250 mg, & 500 mg; Available generically labeled; (OTC)
Thiamine Enteric Coated Tablets 20 mg; Thiamilate® (Tyson) (OTC)
Thiamine HCl for Injection 100 mg/ml in 1, 2, 10 and 30 ml vials & 1 ml amps; Availablegenerically labeled; (Rx)