Doses - TICARCILLIN DISODIUM

Dogs:

For susceptible infections:
a) 15 - 25 mg/kg IV, or IM q8h (Davis 1985)
b) 55 - 110 mg/kg IV, IM or SQ q8h (Aronson and Aucoin 1989)
c) Using the ticarcillin/clavulanate product (usually for Pseudomonas spp. infections): 40 - 110 mg/kg IV or IM q6h (Vaden and Papich 1995)

Cats:

For susceptible infections:
a) 15 - 25 mg/kg IV, or IM q8h (Davis 1985)
b) 55 - 110 mg/kg IV, IM or SQ q8h (Aronson and Aucoin 1989)

Horses:

For susceptible systemic infections:
a) 44 mg/kg q5h IV or tid IM. (Robinson 1987)
b) Foals: 50 mg/kg IV q6-8h (Dose extrapolated from data obtained from adult horses; use lower dose or longer interval in premature foals or those less than 7 days old.) (Caprile and Short 1987)
For treatment of endometritis secondary to susceptible bacteria:
a) 6 grams intrauterine per day for 3 days during estrus. Reconstitute vial with 25 ml of
Sterile Water for Injection, USP or Sodium Chloride Injection, USP. After dissolved, further dilute to a total volume of 100-500 ml with sterile water or sterile normal saline and aseptically instill into uterus. (Package insert; Ticillin®¯Beecham)

Birds:

For susceptible infections:
a) 200 mg/kg IV or IM bid, tid or qid (Clubb 1986)
b) 200 mg/kg IM or IV q8h (Hoeffer 1995)
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Ticarcillin Disodium Sterile Powder for Intrauterine Infusion 6 g vial; Ticillin® (Pfizer); (Rx)
Approved for use in horses.

Human-Approved Products:

Ticarcillin Disodium Powder for Injection (contains 5.2 mEq sodium./g) 1 g, 3 g, 6 g, 20 g, & 30 g in vials; Ticar® (SK-Beecham); (Rx)
Also available with human approval is a ticarcillin/clavulanic acid injectable preparation (Timentin®¯Beecham) that would be effective against many penicillinase-producing strains of bacteria, such as most Staphylococcus species.