Doses - URSODIOL
Dogs: 
For adjunctive treatment of chronic hepatitis: a) 5 - 15 mg/kg PO divided q12h, with immunosuppressive therapy. (Note: Use of this drug at thisdose is preliminary, but promising) (Johnson and Sherding 1994)
b) 10 - 15 mg/kg PO once daily (Leveille-Webster and Center 1995)
Cats: 
For adjunctive treatment of chronic hepatitis: a) 10 - 15 mg/kg PO once daily (Leveille-Webster and Center 1995)
Monitoring Parameters - 1) Efficacy (ultrasonography for gallstones; improved liver functiontests for chronic hepatic disease); 2) Monitoring of SGPT/SGOT (AST/ALT) on a routine basis (inhumans these tests are recommended to be performed at the initiation of therapy and at 1 and 3months after starting therapy; then every 6 months).
Client Information - Because ursodiol dissolves more rapidly in the presence of bile or pancreaticjuice, it should be given with food.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None