KETOROLAC TROMETHAMINE (OPHTHALMIC)

Indications/Pharmacology

Ketorolac tromethamine is a pyrrolol-pyrrole nonsteroidal antiinflammatory agent that inhibits prostaglandin formation. Prostaglandins mediate inflammation within theeye by disrupting the blood-aqueous barrier, inducing vasodilation and increasing intraocular pressure.
Prostaglandins may also cause iris sphincter constriction (miosis) independent of cholinergicmechanisms. Ketorolac tromethamine is marketed for use before cataract extraction in human patients (toprevent miosis during surgery) and for control of post surgical inflammation, especially following cataractsurgery. It is also approved for management of conjunctivitis associated with seasonal allergy in people.
In veterinary medicine, ketorolac tromethamine is primarily used to control surgical or nonsurgical uveitisparticularly in cases with concurrent corneal infection when topical corticosteroids are contraindicated orin diabetic patients, especially smaller patients, adversely affected by systemic uptake of topically appliedcorticosteroids. Nonsteroidal agents like ketorolac tromethamine can be combined with topical steroids inpatients with severe uveal inflammation.Suggested Dosages/Precautions/Adverse Effects - Prior to surgery: One drop 4 times at 20 minuteintervals. One drop four times daily following cataract surgery or for treatment of uveitis or formanagement of allergic conjunctivitis.
The manufacturer indicates that ketorolac tromethamine does not enhance the spread of preexistingcorneal fungal, viral or bacterial infections in animals models. Ketorolac tromethamine does not in and ofitself induce postoperative pressure elevation other then that which frequently follows cataract extractionin people and animals.Dosage Forms/Preparations/FDA Approval Status - Veterinary-Approved Products: None