Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Cestex® (epsiprantel) Veterinary Tablets

Product Type: PRESCRIPTION ANIMAL DRUG LABEL
Autor Name: Pfizer Animal Health
Code Source: 61106-8035
Route of Administration: ORAL

Cestex

Generic: epsiprantel

Ingredients:

  • epsiprantel epsiprantel : Active ingredient - basis of strength - 12.5 mg in 1 1

Package Description:

  • 50 1 in 1 BOTTLE
  • 100 1 in 1 BOTTLE

Cestex

Generic: epsiprantel

Ingredients:

  • epsiprantel epsiprantel : Active ingredient - basis of strength - 25 mg in 1 1

Package Description:

  • 50 1 in 1 BOTTLE
  • 100 1 in 1 BOTTLE

Cestex

Generic: epsiprantel

Ingredients:

  • epsiprantel epsiprantel : Active ingredient - basis of strength - 50 mg in 1 1

Package Description:

  • 25 1 in 1 BOTTLE
  • 50 1 in 1 BOTTLE

Cestex

Generic: epsiprantel

Ingredients:

  • epsiprantel epsiprantel : Active ingredient - basis of strength - 100 mg in 1 1

Package Description:

  • 25 1 in 1 BOTTLE
  • 50 1 in 1 BOTTLE

CAUTION

Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cestex (epsiprantel) tablets are indicated for the removal of tapeworms in the cat (Dipylidium caninum and Taenia taeniaeformis) and dog (Dipylidium caninum and Taenia pisiformis) .

DESCRIPTION

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet.
Epsiprantel is an anthelmintic that is active as a single dose against the common tapeworms of cats and dogs. Epsiprantel has a molecular weight of 326 and is chemically 2-(cyclohexyl-carbonyl)-4-oxo 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benza-zepine. It is a stable white solid which is sparingly soluble in water. Its chemical structure is presented below.

Chemical Structure
Cestex  ®  (epsiprantel) Veterinary Tablets

Pfizer Animal Health
Cestex  ®  (epsiprantel) Veterinary Tablets

ACTION

Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed following oral administration, epsiprantel remains at the site of action within the gastrointestinal tract. Due to digestive process, tapeworm fragments or proglottids may not be readily visible in the stool.

INDICATIONS

Cestex tablets are indicated for the removal of the following:
Feline cestodes: Dipylidium caninum and Taenia taeniaeformis
Canine cestodes: Dipylidium caninum and Taenia pisiformis

DOSAGE AND ADMINISTRATION

Cestex tablets should be administered orally.
The recommended dosage of epsiprantel is: cats, 1.25 mg/lb of body weight; dogs, 2.5 mg/lb of body weight. The following table may be used as a guide:
Dosage Schedule
Feline
Body Weight Dose
Seven weeks old up to 10 lb 12.5 mg
11-20 lb 25.0 mg
Canine
Body Weight Dose
Seven weeks old up to 5 lb 12.5 mg
6-10 lb 25.0 mg
11-20 lb 50.0 mg
21-40 lb 100.0 mg
41-50 lb 125.0 mg
51-60 lb 150.0 mg
61-80 lb 200.0 mg
81-90 lb 225.0 mg
91-100 lb 250.0 mg
101+ lb 2.5 mg/lb, rounding up to next whole tablet combination
Fasting is not necessary or recommended.
Unless exposure to the infected intermediate hosts is controlled, reinfection is likely and retreatment may be required. In the case of D. caninum , an effective flea control program should be instituted.

SAFETY

Epsiprantel has been evaluated in cats at 5 times the recommended dose given once daily for 3 days with no adverse effects noted. In tolerance studies, epsiprantel produced minimal clinical signs in cats given 40 times the recommended dose once daily for 4 days.
Epsiprantel has been evaluated in 14-day repeat dose studies in dogs at 500 mg/kg (90 times recommended dosage) with no significant adverse results. No side effects were observed during the clinical field studies.
Epsiprantel is not a cholinesterase inhibitor. During the course of clinical field studies, Cestex was administered concurrently with diethylcarbamazine citrate (dogs only), anti-inflammatory agents, insecticides, and nematocides with no drug incompatibilities noted.

CONTRAINDICATIONS

There are no known contraindications to the use of this drug.

WARNINGS

For use in cats and dogs only. Safety of use in pregnant or breeding animals has not been determined. Keep out of reach of children. Not for use in humans.

PRECAUTION

Do not use in kittens or puppies less than 7 weeks of age.

STORAGE

Store at controlled room temperature 15 °-30°C (59°-86°F).

HOW SUPPLIED

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet. Cestex is supplied as described below:
Weight (lbs) Number Tablets/Bottle
Concentration Cat Dog
12.5 mg 10 5 50, 100
25.0 mg 20 10 50, 100
50.0 mg - - 20 25, 50
100.0 mg - - 40 25, 50


NADA #140-893, Approved by FDA
75-8032-10
January 2004

PRINCIPAL DISPLAY PANEL - 50 12.5 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
12.5 mg
50 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 50 12.5 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 100 12.5 Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
12.5 mg
100 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 100 12.5 Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 50 25 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
25 mg
50 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 50 25 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 100 25 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
25 mg
100 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 100 25 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 25 50 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
50 mg
25 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 25 50 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 50 50 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
50 mg
50 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 50 50 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 25 100 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
100 mg
25 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 25 100 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

PRINCIPAL DISPLAY PANEL - 50 100 mg Tablet Bottle Label

Cestex ®
(epsiprantel)
Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.
100 mg
50 tablets
NADA #140-893, Approved by FDA
Pfizer

PRINCIPAL DISPLAY PANEL - 50 100 mg Tablet Bottle Label
Cestex  ®  (epsiprantel) Veterinary Tablets

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