Doses - AUROTHIOGLUCOSE

Dogs:

For canine pemphigus foliaceus/vulgaris:
a) For those cases where corticosteroids and/or azathioprine are ineffective or causingunacceptable adverse effects: Discontinue azathioprine for one month and then give 1mg/5kg of body weight IM weekly for 10 weeks and then monthly thereafter. Note:
Before treating, the reader is advised to refer to the full reference for additional information. (Kummel 1995)
b) Test dose of 1 - 5 mg IM, then 1 mg/kg IM weekly until remission, then monthly (Morgan 1988)

Cats:

a) Give animal test dose of 1 mg IM the first week and 2 mg the second week. If no adverse reactions seen (see adverse effects), give 1 mg/kg IM once weekly until either clinical improvement, toxic reactions occur, or weekly dosing has gone on for 20 weeks.
Once remission is achieved, attempt to reduce dose and/or increase dosing interval todenote animals that have gone into remission. (Long 1986)
b) Test dose of 1 - 5 mg IM, then 1 mg/kg IM weekly until remission, then monthly(Morgan 1988)
c) First week 1 mg IM, 2nd week 2 mg IM; then 1 mg/kg once weekly IM decreasing toonce per month (Kirk 1986)

Horses:

a) 1 mg/kg IM once a week decreasing to once a month (Schultz 1986)
Monitoring Parameters -

1) Urinalysis¯baseline, then weekly

2) CBC - baseline, then every 2 weeks
After the patient is on maintenance therapy, hemograms and urinalyses may be done everymonth or two.
Client Information - Clients should be instructed to notify the veterinarian if pruritis, rash, ordiarrhea develops, or if the animal becomes ill or depressed.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None