CLOPROSTENOL SODIUM
Chemistry - A synthetic prostaglandin of the F class, cloprostenol sodium occurs as a white oralmost white, amorphous, hygroscopic powder. It is freely soluble in water and alcohol. Potency ofthe commercially available product is expressed in terms of cloprostenol.
In normally cycling animals, estrus will generally occur 2-5 days after treatment. In pregnant cattletreated between 10-150 days of gestation, abortion will usually occur 2-3 days after injection. Uses, Indications - Cloprostenol (Estrumate®¯Miles) is approved for use in beef or dairy cattleto induce luteolysis. It is recommended by the manufacturer for unobserved or undetected estrus incows cycling normally, pyometra or chronic endometritis, expulsion of mummified fetus, lutealcysts, induced abortions after mismating and to schedule estrus and ovulation for controlledbreeding.
Contraindications/Precautions - Cloprostenol is contraindicated in pregnant animals whenabortion or induced parturition is not desired.
Do not administer IV.
Women of child-bearing age, persons with asthma or other respiratory diseases should use extreme caution when handling cloprostenol as the drug may induce abortion or acute bronchoconstriction. Cloprostenol is readily absorbed through the skin and must be washed off immediatelywith soap and water.
Overdosage - The manufacturer states that at doses of 50 and 100 times those recommended, cattlemay show symptoms of uneasiness, slight frothing and milk let-down.
Overdoses of cloprostenol or other synthetic prostaglandin F2alpha analogs in small animalsreportedly can result in shock and death.
Storage, Stability, Compatibility
Cloprostenol sodium should be stored at room temperature(15-30°C); protect from light.Pharmacology - CLOPROSTENOL SODIUM
Prostaglandin F2alpha and its analogues cloprostenol and fluprostenol are powerful luteolytic agents. They cause rapid regression of the corpus luteum and arrest its secretory activity. These prostaglandins also have direct stimulating effect on uterine smooth muscle causing contraction and a relaxant effect on the cervix.In normally cycling animals, estrus will generally occur 2-5 days after treatment. In pregnant cattletreated between 10-150 days of gestation, abortion will usually occur 2-3 days after injection. Uses, Indications - Cloprostenol (Estrumate®¯Miles) is approved for use in beef or dairy cattleto induce luteolysis. It is recommended by the manufacturer for unobserved or undetected estrus incows cycling normally, pyometra or chronic endometritis, expulsion of mummified fetus, lutealcysts, induced abortions after mismating and to schedule estrus and ovulation for controlledbreeding.
Pharmacokinetics - CLOPROSTENOL SODIUM
No information was located on the pharmacokinetics of cloprostenol.Contraindications/Precautions - Cloprostenol is contraindicated in pregnant animals whenabortion or induced parturition is not desired.
Adverse Effects, Warnings
The manufacturer does not list any adverse effects for this productwhen used as labeled. If used after the 5th month of gestation, increased risk of dystocia and decreased efficacy occur.Do not administer IV.
Women of child-bearing age, persons with asthma or other respiratory diseases should use extreme caution when handling cloprostenol as the drug may induce abortion or acute bronchoconstriction. Cloprostenol is readily absorbed through the skin and must be washed off immediatelywith soap and water.
Overdosage - The manufacturer states that at doses of 50 and 100 times those recommended, cattlemay show symptoms of uneasiness, slight frothing and milk let-down.
Overdoses of cloprostenol or other synthetic prostaglandin F2alpha analogs in small animalsreportedly can result in shock and death.