Doses - CLOPROSTENOL SODIUM

Cattle:

For treatment of pyometra:
a) 500 micrograms IM (up to 97% efficacy) (McCormack 1986)
For pyometra or chronic endometritis, mummified fetus (manual assistance may be required toremove from vagina), luteal cysts:
a) 500 micrograms IM (Package Insert; Estrumate®¯Miles/Mobay)
For unobserved or undetected estrus in cows with continued ovarian cyclicity an a maturecorpus luteum:
a) 500 micrograms IM; estrus should commence in 2-5 days at which time the animal maybe inseminated. If estrus detection is not possible or practical animal may be inseminated twice at 72 and 96 hours post injection. (Package Insert;
Estrumate®¯Miles/Mobay)
For abortion, from one week after mating to approximately the 150th day of gestation:
a) 500 micrograms IM; abortion generally takes place in 4-5 days after injection. (Package
Insert; Estrumate®¯Miles/Mobay)
For controlled breeding:
a) Single injection method: Use only animals with mature corpus luteum. Examine rectallyto determine corpus luteum maturity, anatomic normality, and lack of pregnancy. Give500 micrograms cloprostenol IM. Estrus should occur in 2-5 days. Inseminate at usualtime after detecting estrus, or inseminate once at 72 hours post injection, or twice at 72and 96 hours post injection.
Double injection method: Examine rectally to determine if animal is anatomicallynormal, not pregnant, and cycling normally. Give 500 micrograms IM. Repeat dose 11days later. Estrus should occur in 2-5 days after second injection. Inseminate at usualtime after detecting estrus, or inseminate once at 72 hours post second injection, or twiceat 72 and 96 hours post second injection.
Animals that come into estrus after first injection may be inseminated at the usual timeafter detecting estrus.
Any controlled breeding program should be completed by either observing animals andre-inseminating or hand mating after returning to estrus, or turning in clean-up bull(s)five to seven days after the last injection of cloprostenol to cover any animals returningto estrus. (Package Insert; Estrumate®¯Miles/Mobay)

Horses:

To cause abortion prior to the twelfth day of gestation:
a) 100 micrograms IM, most effective day 7 or 8 post estrus. Mare will usually return toestrus within 5 days. (Lofstedt 1986)

Swine:

To induce parturition in sows:
a) 175 micrograms IM; give 2 days or less before anticipated date of farrowing. Farrowinggenerally occurs in approximately 36 hours after injection. (Pugh 1982)

Sheep & Goats:

To induce parturition in does:
a) 62.5 - 125 micrograms IM at 144 days of gestation in early morning. Deliveries willpeak at 30-35 hours after injection. Maintain goat in usual surrounding and minimizeoutside disturbances. (Williams 1986)
Client Information - Cloprostenol should be used by individuals familiar with its use and precautions. Pregnant women, asthmatics or other persons with bronchial diseases should handle thisproduct with extreme caution. Any accidental exposure to skin should be washed off immediately.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Cloprostenol Sodium Injection Equiv. to 250 micrograms/ml cloprostenol in 10 ml or 20 mlvials; Estrumate® (Bayer); (Rx) Approved for use in beef and dairy cattle. No preslaughterwithdrawal nor milk withdrawal is required; no specific tolerance for cloprostenol residueshave been published.
Human-Approved Products: None