Doses - CLOXACILLIN SODIUM, CLOXACILLIN BENZATHINE
Author's (Plumb) note: Injectable form is not available in the U.S.A.Dogs:
For susceptible infections:
a) 20 - 40 mg/kg PO q8h (Vaden and Papich 1995)
b) 10 - 15 mg/kg q6h PO, IV, or IM (Greene 1984)
c) For Staph. diskospondylitis or skin infections: 10 mg/kg PO qid (Morgan 1988)
d) For Staph. osteomyelitis: 10 mg/kg PO q6h (Ford and Aronson 1985)
e) For Staph. diskospondylitis: 10 mg/kg qid PO for 4-6 weeks (Kornegay 1986)Cats:
For susceptible infections:
a) 20 - 40 mg/kg PO or IM q6-8h (Papich 1988)
b) 10 - 15 mg/kg q6h PO, IV, or IM (Greene 1984)
c) For Staph. diskospondylitis or skin infections: 10 mg/kg PO qid (Morgan 1988)
d) For Staph. osteomyelitis: 10 mg/kg PO q6h (Ford and Aronson 1985)
e) 10 mg/kg PO, IM, or IV q6h (Kirk 1989)Cattle:
For mastitis (treatment or prophylaxis) caused by susceptible organisms:
a) Lactating cow (using lactating cow formula; Dari-Clox®): After milking out and disinfecting teat, instill contents of syringe; massage. Repeat q12h for 3 total doses.
Dry (non-lactating) cows (using dry cow formula; benzathine): After last milking (orearly in the dry period), instill contents of syringe and massage into each quarter.(Package inserts; Dari-Clox®, Orbenin-DC®¯Beecham; Dri-Clox®¯Fort Dodge)
Client Information - Unless otherwise instructed by the veterinarian, this drug should be givenorally on an empty stomach, at least 1 hour before feeding or 2 hours after. Keep oral solution inthe refrigerator and discard any unused suspension after 14 days.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Cloxacillin Benzathine 500 mg (of cloxacillin) in a peanut-oil gel; 10 ml syringe for intramammary infusion
Orbenin-DC® (Pfizer), Dry-Clox® (Fort Dodge); (Rx) Approved for use in dairy cowsduring the dry period (immediately after last milking or early in the dry period). Do notuse within 30 days prior to calving (28 days for Orbenin-DC®). Slaughter withdrawal =30 days (28 days for Orbenin-DC®). A tolerance of 0.01 ppm has been established fornegligible residues in uncooked edible meat and milk from cattle.
Cloxacillin Sodium 200 mg (of cloxacillin) in vegetable oils; 10 ml syringe for intramammaryinfusion
Dari-Clox® (Pfizer); (Rx) Approved for use in lactating dairy cows. Milk withdrawal = 48hours; Slaughter withdrawal = 10 days.
Cloxacillin Sodium Powder for Oral Solution 125 mg/5 ml in 100 & 200 ml bottles; Tegopen® (Apothecon) (Rx), generic; (Rx)
Dogs: 
For susceptible infections: a) 20 - 40 mg/kg PO q8h (Vaden and Papich 1995)
b) 10 - 15 mg/kg q6h PO, IV, or IM (Greene 1984)
c) For Staph. diskospondylitis or skin infections: 10 mg/kg PO qid (Morgan 1988)
d) For Staph. osteomyelitis: 10 mg/kg PO q6h (Ford and Aronson 1985)
e) For Staph. diskospondylitis: 10 mg/kg qid PO for 4-6 weeks (Kornegay 1986)
Cats: 
For susceptible infections: a) 20 - 40 mg/kg PO or IM q6-8h (Papich 1988)
b) 10 - 15 mg/kg q6h PO, IV, or IM (Greene 1984)
c) For Staph. diskospondylitis or skin infections: 10 mg/kg PO qid (Morgan 1988)
d) For Staph. osteomyelitis: 10 mg/kg PO q6h (Ford and Aronson 1985)
e) 10 mg/kg PO, IM, or IV q6h (Kirk 1989)
Cattle: 
For mastitis (treatment or prophylaxis) caused by susceptible organisms: a) Lactating cow (using lactating cow formula; Dari-Clox®): After milking out and disinfecting teat, instill contents of syringe; massage. Repeat q12h for 3 total doses.
Dry (non-lactating) cows (using dry cow formula; benzathine): After last milking (orearly in the dry period), instill contents of syringe and massage into each quarter.(Package inserts; Dari-Clox®, Orbenin-DC®¯Beecham; Dri-Clox®¯Fort Dodge)
Client Information - Unless otherwise instructed by the veterinarian, this drug should be givenorally on an empty stomach, at least 1 hour before feeding or 2 hours after. Keep oral solution inthe refrigerator and discard any unused suspension after 14 days.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Cloxacillin Benzathine 500 mg (of cloxacillin) in a peanut-oil gel; 10 ml syringe for intramammary infusion
Orbenin-DC® (Pfizer), Dry-Clox® (Fort Dodge); (Rx) Approved for use in dairy cowsduring the dry period (immediately after last milking or early in the dry period). Do notuse within 30 days prior to calving (28 days for Orbenin-DC®). Slaughter withdrawal =30 days (28 days for Orbenin-DC®). A tolerance of 0.01 ppm has been established fornegligible residues in uncooked edible meat and milk from cattle.
Cloxacillin Sodium 200 mg (of cloxacillin) in vegetable oils; 10 ml syringe for intramammaryinfusion
Dari-Clox® (Pfizer); (Rx) Approved for use in lactating dairy cows. Milk withdrawal = 48hours; Slaughter withdrawal = 10 days.
Human-Approved Products:
Cloxacillin Sodium Capsules 250 mg, 500 mg; Tegopen® (Apothecon) (Rx), Cloxapen® (SK-Beecham) (Rx), generic; (Rx)Cloxacillin Sodium Powder for Oral Solution 125 mg/5 ml in 100 & 200 ml bottles; Tegopen® (Apothecon) (Rx), generic; (Rx)