Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - DANTROLENE SODIUM

Dogs: Dog

For treatment of functional urethral obstruction due to increased external urethral tone:
a) 1 - 5 mg/kg PO q8h (Polzin and Osborne 1985), (Chew, DiBartola, and Fenner 1986)
b) 3 - 15 mg/kg PO divided bid-tid (Morgan 1988)
For adjunctive treatment of Black Widow Spider bite:
a) 1 mg/kg IV; followed by 1 mg/kg PO q4h (Bailey 1986a)

Cats: Cat

For treatment of functional urethral obstruction due to increased external urethral tone:
a) 0.5 - 2 mg/kg PO q8h (Polzin and Osborne 1985)

Horses: Horse

For treatment of acute rhabdomyolosis:
a) 15 - 25 mg/kg slow IV qid (Robinson 1987)
For prevention of rhabdomyolysis:
a) 2 mg/kg PO once daily (Robinson 1987)
For prevention of post-anesthetic myositis (PAM):
a) 10 mg/kg PO (intragastric) 1.5 hours before surgery. This should give peak levels at thetime surgery begins and maintain postulated therapeutic levels for an additional 2 hours.
The intragastric preparation was made by dissolving/suspending the contents of oralcapsules into 500 ml of normal saline. Should further doses be warranted, additionaldoses of 2.5 mg/kg PO (intragastric) q60 minutes can be given.
Alternatively, IV doses of 1.9 mg/kg loading will give therapeutic levels but will onlypersist for about 20 minutes. An IV dose of 4 mg/kg will maintain therapeutic levels forabout 2 hours but peak levels will be quite high. (Court et al. 1987)

Swine: Swine

Prevention or treatment of malignant hyperthermia:
a) 3.5 mg/kg IV (Booth 1988a)
Monitoring Parameters -
Depending on the reason for use:
  • 1) Baseline and periodic liver function tests (ALT, AST, Alk Phos, etc) if projecting to beused chronically or using high dosages
  • 2) Body temperature (malignant hyperthermia)
  • 3) Urine volume, frequency, continence
    Client Information - This drug should only be used by professionals familiar with its use.
    Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

    Human-Approved Products:

    Dantrolene Sodium 25 mg, 50 mg, 100 mg capsules; Dantrium® (Procter & Gamble Pharm.)(Rx)
    Dantrolene Sodium for Injection 20 mg per vial (with mannitol 3 g.); Dantrium® Intravenous(Procter & Gamble Pharm.) (Rx)
    Note: Because of the expense, minimum order quantity, and non-returnable nature of the commercially available intravenous product, it is not well suited for veterinary use.
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