DECOQUINATE

Chemistry - A coccidiostat, decoquinate occurs as a cream to buff-colored fine amorphous powderhaving a slight odor. It is insoluble in water.

Storage, Stability, Compatibility

Decoquinate is reportedly incompatible with strong bases oroxidizing material. Follow label storage directions; store in a cool, dry place. Deccox® is labeled asbeing compatible (and cleared for use) with bacitracin zinc (with or without roxarsone), chlortetracycline, and lincomycin.

Pharmacology - DECOQUINATE

Decoquinate is 4-hydroxy quinolone agent that has anticoccidial activity.
Decoquinate act on the sporozoite stage of the life cycle. The sporozoite apparently can stillpenetrate the host intestinal cell, but further development is prevented. The mechanism of action fordecoquinate is to disrupt electron transport in the mitochondrial cytochrome system of coccidia.

Uses, Indications

Decoquinate is labelled for use in cat le for the prevention of coccidiosis ineither ruminating or non-ruminating calves, cat le or young goats caused by the species E. christenseni or E. ninakohlyakimoviae . It is used for prevention of coccidiosis in broilers caused by E.tenella, E. necatrix, E. acervulina, E. mivati, E. maxima or E. burnetti.

Pharmacokinetics - DECOQUINATE

No information located.

Contraindications, Precautions, Reproductive Safety

Decoquinate is not effective for treatingclinical coccidiosis and has no efficacy against adult coccidia. Decoquinate is not approved for usein animals producing milk for food or in laying chickens.

Adverse Effects, Warnings

No adverse effects listed when given as directed.

Overdosage, Acute Toxicity

No specific information located. Decoquinate is considered to havea wide safety margin.
Drug Interactions/Laboratory Considerations - None located.