Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - DINOPROST TROMETHAMINE, PROSTAGLANDIN F2aTROMETHAMINE

Dogs:

For treatment of pyometra:
a) 0.25 mg/kg SQ once a day for 5 days. Give bactericidal antibiotics concurrently. Notrecommended in animal > 8 yrs. old or if severely ill. Closed-cervix pyometra is arelative contraindication. (Nelson 1988)
b) 0.025 - 0.25 mg/kg every 12 hours to effect. Initially use lower dosage to determineadverse effects on patient. Dosage depends on adverse effects and clinical condition ofanimal. For small dogs and cats: Dilute 1 ml (5 mg) of dinoprost injection to 25 ml withsterile water for injection, which will yield a concentration of 0.2 mg/ml (200micrograms/ml). Adjunctive therapy includes systemic antibiotics (e.g., chloramphenicol, trimethoprim/sulfa, ampicillin) and anterior vaginal douches with 200-500 ml warm 1% tamed iodine (povidone iodine) solution daily during prostaglandin treatment. (Lein 1986)
c) 0.05 mg/kg (50 micrograms/kg) every 12 hours (Wheaton 1989)
For treatment of cystic endometrial hyperplasia-pyometra:
a) 0.1 - 0.25 mg/kg once daily until discharge stops, but not for more than 5 days; reexamine in 2 weeks. If discharge has recurred, treat at 0.25 - 0.5 mg/kg as above. Do not give a third course of therapy. Concurrent antibiotic treatment is necessary. (Shille 1986)
As an abortifacient:
a) All doses are quoted using the THAM salt (Lutalyse®):
During the first half of gestation: 250 micrograms/kg every 12 hours SubQ for 4 days, starting at least 5 days after cytologic diestrus. After the eighth injection, draw bloodsample for serum progesterone concentration. Examine several weeks post treatment toverify pregnancy termination (failures have been reported).
During second half of gestation: Verify preganancy (palpation/ultrasound). Inject 250micrograms/kg SubQ every 12 hours until abortion is complete. Treatment efficacy isdetermined by monitoring the completeness of pregnancy termination. (Root and Johnston 1995)
b) In healthy bitches from midgestation to term: 25 - 250 micrograms/kg IM twice a day.
Hospitalization and close monitoring essential. Vaginoscopy done daily to detect dilation of cervix. Radiography or ultrosonagraphy done every 3-5 days during treatment to determine if abortion is complete. (Lein 1986)

Cats:

For treatment of pyometra:
a) Initially 0.1 mg/kg SQ, then 0.25 mg/kg SQ once a day for 5 days. Give bactericidalantibiotics concurrently. Not recommended in animals > 8 yrs. old or if severely ill.
Closed-cervix pyometra is a relative contraindication. Reevaluate in 2 weeks; retreat for5 more days if necessary. (Nelson 1988), (Feldman and Nelson 1989)
b) Same as for dogs above (Lein 1986)
As an abortifacient:
a) After day 40 of gestation: 0.5 - 1.0 mg/kg SQ initially and then 24 hours later. Abortiongenerally ensues in 8-24 hours. (Woody 1988)

Cattle:

For estrus synchronization in beef cattle and non-lactating dairy heifers:
a) 25 mg IM either once or twice at a 10-12 day interval. If using single injection method, breed at usual time relative to estrus. If using dual dose method, breed at either the usualtime relative to estrus, or about 80 hours after the second injection. (Package Insert;
Lutalyse®¯Upjohn)
For unobserved (silent) estrus in lactating dairy cattle with a corpus luteum:
a) 25 mg IM. Breed cows as they are detected in estrus. If estrus not detected, breed at 80hours post injection. If cow returns to estrus, breed at usual time relative to estrus.(Package Insert; Lutalyse®¯Upjohn)
For pyometra:
a) 25 mg IM. Uterus begins evacuating within 24 hours of injection. (McCormack 1986), (Package Insert; Lutalyse®¯Upjohn)
As an abortifacient:
a) Between 5-150 days of gestation: 25 - 30 mg IM
After 150 days of gestation: 25 mg dexamethasone with 25 mg dinoprost (efficacy up to95%) (Drost 1986)
b) 25 mg IM during the first 100 days of gestation (Package Insert; Lutalyse®¯Upjohn)
To induce parturition:
a) 25 - 30 mg IM; delivery will occur in about 72 hours (Drost 1986)

Horses:

To induce cyclic activity in animals who are acyclic due to persistent corpus lutea:
a) 5 mg IM; most effective in mares with corpora lutea older than 5 days and who haveprogesterone levels >1 ng/ml (4 ng/ml even better). (Rossdale 1987)
For difficult to breed mares secondary to progesterone levels consistent with the presence of afunctional corpus luteum:
a) 1 mg per 45 kg body weight IM (Package Insert; Lutalyse®¯Upjohn)
For controlling time of estrus of estrous cycling mares:
a) 1 mg per 45 kg body weight IM. When treated during diestrus, most mares return toestrus in 2-4 days and ovulate 8-12 days after treatment. (Package Insert;
Lutalyse®¯Upjohn)
As an abortifacient:
a) Prior to the 12th day of pregnancy: 5 mg IM
After the 4th month of pregnancy: 1 mg per 45 kg body weight (1 mg per 100 pounds)daily until abortion takes place. (Lofstedt 1986)
b) From day 80-300: 2.5 mg q12h; approximately 4 injections required on average to induce abortion (Roberts 1986a)
For estrus synchronization in normally cycling mares:
a) Three methods:
  • 1) Two injection method¯ On day 1 give 5 mg dinoprost and again on day 16. Most (60%) mares will begin estrus 4 days after the second injection and about 90% willshow estrous behavior by the 6th day after the second injection. Breed using AI every second day during estrus or inseminate at predetermined times without estrus detection.
    Alternatively, an IM injection of HCG (2500-3300 Units) can be added on the first or second day (usually day 21) of estrus to hasten ovulation. Breed using AI on days 20, 22, 24, and 26. This may be of more benefit when used early in the breeding season.
  • 2) Progestagen/Prostaglandin method¯ Give altrenogest (0.44 mg/kg) for 8-12 days
    PO. On last day of altrenogest therapy (usually day 10) give dinoprost (dose not noted, but suggest using same dose as "1" above). Majority of mares will show estrus 2-5days after last treatment. Inseminante every 2 days after detection of estrus.
    Synchronization may be improved by giving 2500 IU of HCG IM on first or secondday of estrus or 5-7 days after altrenogest is withdrawn.
  • 3) On day 1, inject 150 mg progesterone and 10 mg estradiol-17beta daily for 10 days.
    On last day, also give dinoprost (dose not noted, but suggest using same dose as "1"above). Perform AI on alternate days after estrus detection or on days 19, 21, and 23.(Bristol 1987)

    Swine:

    For estrus synchronization (grouping):
    a) At 15-55 days of gestation 15 mg dinoprost IM, followed in 12 hours by 10 mg IM.
    Animals will abort and return to estrus in 4-5 days. Close observation of estrus over several days is needed. (Carson 1986)
    As an abortifacient:
    a) 5 - 10 mg IM; abortion occurs in 24-48 hours and estrus occurs 4-5 days later. (Drost 1986)
    To induce parturition:
    a) 10 - 25 mg IM from 2-6 days before expected parturition; farrowing usually occurs 24-36 hours later. (Drost 1986)

    Sheep & Goats:

    For estrus synchronization in cycling ewes and does:
    a) Ewes: Give 8 mg IM on day 5 of estrous cycle and repeat in 11 days. Estrus will begin approximately 2 days after last injection.
    Does: Give 8 mg IM on day 4 of estrous cycle and repeat in 11 days. Estrus will begin approximately 2 days after last injection. (Carson 1986)
    To induce estrous in does (weighing up to 65 kg):
    a) 2.5 mg on days 4-17 of estrous cycle.
    As an abortifacient:
    a) Doe: 5 - 10 mg IM throughout entire pregnancy. Abortion takes place in 4-5 days.
    Ewe (during first two months of pregnancy): 10 - 15 mg IM; abortion takes place within72 hours. (Drost 1986)
    To induce parturition:
    a) Does: 2.5 - 5.0 mg IM on day 144; parturition occurs in 28-57 hours. (Ott 1986a)
    b) Does: 2.5 - 20 mg on days 144-149. Higher dosage (20 mg) yields more predictableinterval from injection to delivery (ยป32 hours). (Ott 1986b)
    For chronic metritis/pyometra:
    a) Doe: 2.5 - 5.0 mg SQ with systemic antibiotics (Franklin 1986b)
    Monitoring Parameters - Depending on use, see above. Monitoring for adverse effects is especially important in small animals.
    Client Information - Dinoprost should be used by individuals familiar with its use and precautions. Pregnant women, asthmatics or other persons with bronchial diseases should handle thisproduct with extreme caution. Any accidental exposure to skin should be washed off immediately.
    Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
    Dinoprost Tromethamine for injection, equivalent to 5 mg/ml of dinoprost in 10 ml and 30 mlvials; Lutalyse® (Upjohn); (Rx) Approved for use in beef and non-lactating dairy cat le, swineand mares. No preslaughter withdrawal or milk withdrawal is required when used as labeled;no specific tolerance for dinoprost residues have been published. It is not for use in horsesintended for food
    Human-Approved Products: None
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