ETHYLISOBUTRAZINE HCL

Chemistry - Ethylisobutrazine is a phenothiazine derivative with similar actions as acepromazine.
Its chemical name is 2-ethyl-10-(3-dimethylamino-2-methypropyl) phenothiazine.

Storage, Stability, Compatibility

Should be protected from light and excessive heat. Injectablesolution should be a colorless to light yellow or amber color. Discard if color deviates from above.

Pharmacology - ETHYLISOBUTRAZINE HCL

The pharmacologic actions of ethylisobutrazine reportedly are very similar toother phenothiazines (e.g., acepromazine), but clinical experience with this agent is much less thanwith acepromazine. For further information on the pharmacologic activity of phenothiazines, pleaserefer to the acepromazine monograph.

Uses, Indications

Ethylisobutrazine is only approved for use in dogs. Approved indications include "..as an aid in controlling intractable patients during many common clinical procedures such as examinations, grooming and administration of medications; to control excessive barking in kennels; to control vomiting associated with motion sickness and with administration of anthelmintics; as an aid in the management of pruritis associated with severe dermatoses, especially those with a tendency toward self-mutilation" (Package Insert; Diquel®¯Coopers).

Pharmacokinetics - ETHYLISOBUTRAZINE HCL

No pharmocokinetic information was located for this agent.
Contraindications/Precautions - Not recommended for use in species other than dogs. Pleaserefer to acepromazine monograph immediately preceding this one for more information regardingphenothiazines. The manufacturer also cautions to carefully observe patients receiving chronictherapy for blood dyscrasias and allergic reactions.

Adverse Effects, Warnings

Refer to the acepromazine monograph for more information regarding phenothiazines.
Overdosage - No information on overdoses was located regarding this agent; refer to the information for acepromazine for general guidelines regarding phenothiazine overdoses.

Drug Interactions

Ethylisobutrazine should not be given within one month of worming with anorganophosphate agent as their effects may be potentiated. Other CNS depressant agents(barbiturates, narcotics, anesthetics, etc.) may cause additive CNS depression if used withethylisobutrazine.
Quinidine when given with phenothiazines may cause additive cardiac depression.
Antidiarrheal mixtures (e.g., Kaolin/pectin, bismuth subsalicylate mixtures) and antacids maycause reduced GI absorption of oral phenothiazines. Increased blood levels of both drugs mayresult if propranolol is administered with phenothiazines. Phenothiazines block alpha-adrenergicreceptors which, if epinephrine is given, can lead to unopposed beta-activity causing vasodilationand increased cardiac rate.
Phenytoin metabolism may be decreased if given concurrently with phenothiazines.
Procaine activity may be enhanced by phenothiazines.