Doses - ETRETINATE, ACITRETIN
Dogs: 
For treating seborrhea: a) In American cocker spaniels: 0.75 - 1 mg/kg PO once daily; may require long termtherapy. (Kwochka 1992)
b) 1 mg/kg PO once daily (q24h); response is seen within 2 months (Kwochka 1994)
For treatment of primary seborrhea in cocker spaniels; primary keratinization disorders/ichthyosis; Schnauzer comedo syndrome; hair follicle dysplasias: 1 mg/kg once daily or divided q12h PO.
For Sebaceous adenitis in Akitas or Samoyeds; Multiple infundibular keratanizing acanthomas: 1 - 2 mg/kg once daily or divided q12h PO.
For actinic keratosis/solar-induced squamous cel carcinoma; epitheliotrophic lymphoma: 2 mg/kg once daily or divided q12h PO. (Power and Ihrke 1995)
For sebaceous adenitis:
a) 1 - 2 mg/kg PO once daily; may be useful particularly in long-coated breeds (Kwochka 1994)
Cats: 
For actinic keratosis/solar-induced squamous cel carcinoma; or Bowen's Disease: 10 mg/catonce daily PO. (Power and Ihrke 1995) Monitoring Parameters - 1) Efficacy; 2) Liver function tests (baseline and if symptoms appear)
3) Schirmer tear tests (monthly¯especially in older dogs)
Client Information - Acitretin should be handled by pregnant women in the household with extreme care, if at all. Veterinarians must take the personal responsibility to educate clients of thepotential risk of ingestion by pregnant females.
Milk or high fat foods will increase the absorption of etretinate. To reduce variability of absorption, either have clients consistently give with meals or not. Long term therapy can be quite expensive.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None