Doses - FLUNIXIN MEGLUMINE
Dogs:
a) 0.5 - 2.2 mg/kg IM or IV one time only (Jenkins 1987) b) 1 mg/kg IM or IV once a day for no longer than 3 days (Davis 1985b)
c) For ocular indications: 0.25 mg/kg IV once daily for no more than 5 days at a time. May also be used preoperatively by injecting IV 30 minutes before ocular surgery. May dilute 1:9 (flunixin: sterile water) in syringe to administer accurately to very small animals. (Wyman 1986)
d) For ocular disease: 0.5 mg/kg IV bid for 1-2 treatments;
For acute gastric dilatation: 1 mg/kg IV once;
For GI tract obstruction: 0.5 mg/kg IV once to twice daily for 3 treatments (Morgan1988)
e) For surgical pain: 1 mg/kg IV, subQ or IM initially once; 1 mg/kg subsequent dailydoses
For pyrexia: 0.25 mg/kg IV, subQ or IM once, may be repeated in 12-24 hours ifneeded
For ophtho procedures: 0.25 - 1 mg/kgIV, IM or SubQ once, may be repeated in 12-24hours if needed (Johnson 1996)
Cats:As an antiinflammatory/analgesic:
For surgical pain: 0.25 mg/kg subQ once; once, may be repeated in 12-24 hours ifneeded
For pyrexia: 0.25 mg/kg IV, subQ or IM once, may be repeated in 12-24 hours ifneeded (Johnson 1996)
Rabbits & Rodents:
a) Rabbits: 1.1 mg/kg SubQ or IM q12h Rodents: 2.5 mg/kg SubQ or IM q12h (Huerkamp 1995)
Cattle:
a) For labeled indications: 1.1 - 2.2 mg/kg (1 -2 mls per 100 lbs. BW) given slow IV either once a day as a single dose or divided into two doses q12h for up to 3 days. Avoid rapid IV administration. (Package Insert; Banamine® ¯ Schering). b) For treatment of radial nerve injury: 250 - 500 mg IV or IM bid, may need only one treatment; taper and discontinue usually after 2-3 days. (Rebhun 1986)
c) For aseptic lameness in cattle: 1.1 mg/kg, must be administered within 24 hrs after onset of symptoms to be effective. (Berg 1986)
d) 2.2 mg/kg then 1.1 mg/kg q8h IV (Jenkins 1987)
Horses:
a) Injectable: 1.1 mg/kg IV or IM once daily for up to 5 days. For colic cases, use IV routeand may redose when necessary. Oral Paste: 1.1 mg/kg PO (see markings on syringe¯calibrated in 250 lb. weight increments) once daily. One syringe will treat a 1000 lb. horse for 3 days. Do not exceed 5 days of consecutive therapy.
Oral Granules: 1.1 mg/kg PO once daily. One packet will treat 500lbs of body weight.
May apply on feed. Do not exceed 5 consecutive days of therapy. (Package Inserts -
Schering Animal Health for Banamine®)
b) 1.1 mg/kg IM or IV q12h to treat moderate to severe pain. (Clark and Becht 1987)
c) 1.1 mg/kg IM or IV; duration of effect averages 4-36 hrs depending upon cause and severity of abdominal pain. (Muir 1987)
Birds:a) 1 - 10 mg/kg IM. May be indicated for pain, shock and trauma. True analgesic effects unknown in avian species, but has no detrimental respiratory effects. Vomiting and straining to defecate may occur after administration. (Wheler 1993)
Monitoring Parameters -
Client Information - If injecting IM, do not inject into neck muscles.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: Flunixin is approved only for use in horses not intended forfood; for beef cattle and non-lactating dairy cattle. Slaughter withdrawal time in cattle = 4 days.
Flunixin Meglumine for Injection 50 mg/ml; in 50 and 100 ml vials; Banamine® (Schering);(Rx)
Flunixin Meglumine Oral Paste 1500 mg/syringe; 30 gram syringe containing 1500 mg flunixinin boxes of 6; Banamine® (Schering); (Rx)
Flunixin Meglumine Oral Granules 250 mg: 10 gram sachets, each sachet contains 250 mgflunixin in boxes of 50. 500 mg: 20 g sachets, each sachet contains 500 mg flunixin in boxesof 25; Banamine® (Schering); (Rx)
Flunixin may also be known as Finadyne®.
Human-Approved Products: None5-Fluorocytosine - see Flucytosine