FLUPROSTENOL SODIUM
Chemistry - A synthetic analogue of prostaglandin F2alpha, fluprostenol sodium occurs as a whiteor almost white hygroscopic powder that is soluble in water and alcohol. The drug's potency isexpressed in terms of fluprostenol; 52.4 micrograms of fluprostenol sodium is equivalent to 50micrograms of fluprostenol.
Uses, Indications - The labeled indications for fluprostenol are to synchronize estrus for breedingmanagement and for postpartum breeding. Suggested therapeutic uses by the manufacturer include:induction of luteolysis following early fetal death and resorption; termination of persistent diestrus;termination of pseudopregnancy; termination of lactational anestrus; establishing estrous cycles inbarren/maiden mares; and to determine if a mare is cycling.
The drug has also been used as an induction agent for parturition and as an abortifacient.
Contraindications/Precautions - Fluprostenol should not be used in pregnant mares unless parturition induction or abortion is desired. It should also not be used in mares with acute or subacute disorders of the GI tract or respiratory disease.
The manufacturer states that mares receiving non-steroidal antiinflammatory drugs should not receive fluprostenol, as this drug can inhibit the synthesis and release of prostaglandins. The clinical significance of such an interaction is in doubt, however.
The manufacturer recommends conducting a through breeding exam prior to the use of this drug.
See the warnings regarding the handling of the agent under Client Information below.
Overdosage - No specific information was located. It would be expected that mild overdoses would result in the adverse effects listed above (sweating, diarrhea, increased respiratory rate). The animal should be treated supportively if necessary.
Storage, Stability, Compatibility
Fluprostenol should be stored in airtight containers and protected from light. The manufacturer recommends discarding any unused product after opening the vial.Pharmacology - FLUPROSTENOL SODIUM
Fluprostenol exhibits pharmacologic effects similar to those of the other agents inthis class. Effects on the female reproductive system include stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and potential lysing ofcorpora lutea. Fluprostenol reportedly has less smooth muscle stimulant activity and, therefore, maybe safer to use to induce parturition in the mare.Uses, Indications - The labeled indications for fluprostenol are to synchronize estrus for breedingmanagement and for postpartum breeding. Suggested therapeutic uses by the manufacturer include:induction of luteolysis following early fetal death and resorption; termination of persistent diestrus;termination of pseudopregnancy; termination of lactational anestrus; establishing estrous cycles inbarren/maiden mares; and to determine if a mare is cycling.
The drug has also been used as an induction agent for parturition and as an abortifacient.
Pharmacokinetics - FLUPROSTENOL SODIUM
No information was located for this agent.Contraindications/Precautions - Fluprostenol should not be used in pregnant mares unless parturition induction or abortion is desired. It should also not be used in mares with acute or subacute disorders of the GI tract or respiratory disease.
The manufacturer states that mares receiving non-steroidal antiinflammatory drugs should not receive fluprostenol, as this drug can inhibit the synthesis and release of prostaglandins. The clinical significance of such an interaction is in doubt, however.
The manufacturer recommends conducting a through breeding exam prior to the use of this drug.
Adverse Effects, Warnings
In horses, sweating, increased respiration, mild abdominal discomfort, uneasiness and defecation may be seen after fluprostenol injection. Adverse effects are more likely at doses above those recommended by the manufacturer.See the warnings regarding the handling of the agent under Client Information below.
Overdosage - No specific information was located. It would be expected that mild overdoses would result in the adverse effects listed above (sweating, diarrhea, increased respiratory rate). The animal should be treated supportively if necessary.