Doses - FLUPROSTENOL SODIUM

Horses:

Manufacturer's suggested dosage for all labeled indications (see above or package insert):
a) 0.55 micrograms/kg (average dose 250 micrograms or 5 ml) IM
To induce parturition in the mare:
a) 2.2 micrograms/kg (0.0022 mg/kg) IM; delivery generally occurs in about 4 hours(Carleton and Threlfall 1986)
b) Pony mares 250 micrograms IM, full-sized mares 1000 micrograms IM. First stage of labor ensues in 30 minutes, onset of second stage labor occurs in about 1/2 -3 hours.
Duration of second stage labor varies from about 5-35 minutes. Author recommends further studies before recommending procedure. (Hillman 1987)
As an abortifacient:
a) Prior to the 12th day of pregnancy: 250 micrograms IM (Lofstedt 1986)
b) Prior to day 35 of gestation: 250 micrograms IM one time; after day 35: 250 micrograms IM daily for 3-5 days are required. (Squires and McKinnon 1987)
For estrus synchronization in normally cycling mares:
a) Two injection method: On day 1 give 250 micrograms (Note: The text from this reference reads: 0.250 micrograms; it is believed that this is an error as the manufacturer's recommended dose is approximately 250 micrograms) and again on day 16. Most (60%) mares will begin estrus 4 days after the second injection and about 90% will show estrous behavior by the 6th day after the second injection. Breed using AI every second day during estrus or inseminated at predetermined times without estrus detection. Alternatively, an IM injection of HCG (2500-3300 Units) can be added on the first or second day (usually day 21) of estrus to hasten ovulation. Breed using AI on days 20, 22, 24, and 26. This may be of more benefit when used early in the breeding season. (Bristol 1987)
Client Information - Fluprostenol should only be used by individuals familiar with its use and precautions. Pregnant women, asthmatics or other persons with bronchial diseases should handle this product with extreme caution. Any accidental exposure to skin should be washed off immediately using soap and water.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Fluprostenol sodium for Injection, equivalent to 50 micrograms/ml fluprostenol in 5 ml vials;
Equimate® (Bayer); (Rx) Approved for use in horses. It is not for use in horses intended for food.
Human-Approved Products: None