Doses - GONADORELIN

Dogs:

GnRH challenge to test pituitary sufficiency or testicular steroidogenesis:
a) 125 - 250 ng/kg (refer to reference for more information) (Amann 1986)
To aid in the descent of cryptorchid testes:
a) 50 - 100 micrograms SQ or IV; if no response give additional dose in 4-6 days (Cox1986)

Cats:

To stimulate ovulation after mating:
a) 25 micrograms IM after mating (Morgan 1988)

Cattle:

To treat of ovarian cysts in cattle:
a) 100 micrograms IM or IV (Package Insert; Cystorelin®¯Ceva)
b) 100 micrograms IM per cow (Package insert; Factrel®¯Fort Dodge)

Sheep & Goats:

To induce ovulation outside of the breeding season in the doe:
a) 100 micrograms injected daily for 4-5 days (Smith 1986b)
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Gonadorelin (diacetate tetrahydrate) for Injection 50 micrograms/ml, 2 ml single-use or 10 mlmulti-dose vials; Cystorelin® (Rhone Merieux); Fertagyl® (Intervet); (Rx) Approved for usein dairy cattle. There are no withdrawal times required for either milk or slaughter.
Gonadorelin HCl Solution for Injection 50 mcg/ml in 2 ml single-use, and 20 ml multi-dosevials; Factrel® (Fort Dodge); (Rx) Approved for use in cattle. No withdrawal period required.

Human-Approved Products:

Gonadorelin Acetate Powder for Injection (lyophilized) 0.8 and 3.2 mg in 10 ml vials;
Lutrepulse® (Ferring) (Rx)
Gonadorelin HCl Powder for Injection 100 mcg/vial, 500 mcg/vial; Factrel® (Wyeth-Ayerst); (Rx)