Doses - ISOXSUPRINE HCL

Horses:

For treatment of navicular disease:
a) 0.6 - 0.66 mg/kg bid PO X 21 days; then once daily for 14 days; then once every otherday for 7 days. (Note: 0.66 mg/kg is fifteen 20 mg tabs for a 1000 lb. horse)
For refractory cases: regimen may be repeated at 1.32 mg/kg. If no improvement seenafter 6 week course then discontinue. (Forney and Allen 1984)
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects (tachycardia, GI disturbances, CNS stimulation)
Client Information - To be maximally effective, doses must be given routinely as directed. Tablets may be crushed and made into a slurry/suspension/paste by adding corn syrup, cherry syrup, etc., just before administration.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Isoxsuprine HCl Tablets 10 mg, 20 mg; Vasodilan® (Mead Johnson), Voxsuprine® (Major), Generic; (Rx)