Cefpodoxime Proxetil
Product Type: PRESCRIPTION ANIMAL DRUG LABEL
Autor Name: Putney, Inc.
Code Source: 26637-332
Route of Administration: oral
Cefpodoxime Proxetil Tablets
For Oral Use in Dogs Only
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
DESCRIPTION
Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic cephalosporin antibiotic. The chemical name is: (+/-)-1-Hydroxyethyl(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 7 2 -(Z)-(0-methyloxime), isopropyl carbonate (ester) [87239-81-4].
Cefpodoxime Proxetil Chemical Structure:
Cefpodoxime proxetil is a prodrug; its active metabolite is cefpodoxime. All doses of Cefpodoxime Proxetil Tablets are expressed in terms of the active cefpodoxime moiety. Cepodoximine Proxitel Tablets are available as:
100 mg Tablet, each yellow, elliptical, scored tablet contains cefpodoxime proxetil equivalent to 100 mg of cefpodoxime.
200 mg Tablet, each orange, oblong, tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime.
Chemical Structure
INDICATIONS
Cefpodoxime Proxetil Tablets are indicated for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius , Staphylococcus aureus , Streptococcus canis (group G, β hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.
DOSAGE AND ADMINISTRATION
Dose Range: The dose range of Cefpodoxime Proxetil Tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.
Duration: Cefpodoxime Proxetil Tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections shouldnot be continued for more than 3-4 days if no response to therapy is seen.
Dosing Charts: For daily oral administration of Cefpodoxime Proxetil Tablets at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).
Table 1. Dose Table for Cefpodoxime Proxetil Tablets at 5 mg/kg Total Daily Dosage
Table 2. Dose Table for Cefpodoxime Proxetil Tablets at 10 mg/kg Total Daily Dosage
CONTRAINDICATIONS
Cefpodoxime proxetil is contraindicated in dogs with known allergy to cefpodoxime or to the β-lactam (penicillins and cephalosporins) group of antibiotics.
WARNINGS
Not for human use. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.
PRECAUTIONS
The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs ` test.
ADVERSE REACTIONS
A total of 216 dogs of various breeds and ages ranging from 2 months to 15 years were included in the field study safety analysis. The following table shows the number of dogs displaying each clinical observation.
Table 3. Abnormal Health Findings in U.S. Field Study 1
1 Dogs may have experienced more than one of the observations during the study.
To report a suspected adverse reaction call 1-866-683-0660.
To request a Material Safety Data Sheet (MSDS) for Cefpodomixe Proxetil Tablets, call 1-866-683-0660.
CLINICAL PHARMACOLOGY
Pharmacokinetics/Pharmacodynamics: Cefpodoxime proxetil is a prodrug that is absorbed from and de-esterified in the gastrointestinal tract to its active metabolite, cefpodoxime. Following oral administration to fasting Beagles, oral bioavailability was 63.1 ± 5.3%.
Figure 1. Canine Plasma Concentration Of Cefpodoxime After A Single Oral Dose Of 10 mg/kg Cefpodoxime Proxetil Tablets
Cefpodoxime is distributed in the body with an apparent volume of distribution of 151 ± 27 mL/kg. Like other β-lactam antibiotics, cefpodoxime is eliminated from the body primarily in the urine, with an apparent elimination half-life of approximately 5-6 hours after oral administration. This is similar to the 4.7 hour apparent elimination half-life observed after intravenous dosing . Following intravenous administration of 10 mg/kg, the average total body clearance (Cl B ) was 22.7 ± 4.19 mL/hr/kg.
Table 4. Summary of Pharmacokinetic Paraemters Obtained after a Single Oral Dose of 10 mg Cefpodoxime/kg BW, Administered as a Tablet
Microbiology: Like other β-lactam antibiotics, cefpodoxime exerts its inhibitory effect by interfering with bacterial cell wall synthesis. This interference is primarily due to its covalently binding to the penicillin-binding proteins (PBPs) (i.e. transpeptidase and/or carboxypeptidase), which are essential for synthesis o f the bacterial cell wall. Therefore, cefpodoxime is bactericidal. Cefpodoxime is stable in the presence of many common β-lactamese enzymes. As a result, many organisms resistant to other β-lactam antibiotics (penicillins and some cephalosporins) due to the production of β-lactamases may be susce ptible to cefpodoxime.
Cefpodoxime has a broad spectrum of clinically useful antibacterial activity that includes staphylococci, streptococci, and Gram-negative species (including Pasteurella, Escherichia, and Proteus ). The compound is not active against most obligate anaerobes, Pseudomonas spp., or enterococci. The minimum inhibitory concentrations (MICs) for cefpodoxime against Gram-positive and Gram-negative pathogens isolated from canine skin infections (wounds and abscesses) in a 2002 U.S. field study are presented in Table 5. All MICs were determined in accordance with the National Committee for Clinical Laboratory Standards (NCCLS). Appropriate quality control (QC) ranges for in vitro susceptibility testing are presented in Table 6.
TABLE 5. Cefpodoxime Minimum Inhibitory Concentration Values (mcg/mL) from a 2002 Field Study Evaluating Skin Infections (wounds and abscesses) of Canines in the United States
† No Range, all isolates yielded the same value.
*Veterinary specific interpretive criteria have not been established for the above listed canine pathogens by the NCCLS at this time.
Table 6. Acceptable Quality Control Ranges for Cefpodoxime
a These ranges are for quality control strains used to monitor accuracy of minimum inhibitory concentrations (MICs) of non-fastidious organisms using cation-adjusted Mueller-Hinton agar or broth medium. The dilution range should encompass the QC ranges of these strains in the broth micro-dilution method.
b These ranges are for quality control strains used to monitor accuracy of minimum inhibitory concentrations (MICs) of fastidious organisms. When susceptibility testing is performed for Streptococcus canis (group G, β hemolytic), Streptococcus pneumoniae ATCC 49619 should be included as a QC strain in the presence of 5% lysed sheep blood (KB disk diffusion method) or 2.5% lysed horse blood (broth micro-dilution method).
Figure 1 PK
EFFECTIVENESS
The clinical effectiveness of cefpodoxime proxetil was established in a multi-location (23 site) field study. In this study, 216 dogs with infected wounds or abscesses were treated with either cefpodoxime proxetil (n=118) once daily at 5 mg/kg (2.3 mg/lb) body weight or with a active control antibiotic (n=98) administered twice daily for 5-7 days. In this study, cefpodoxime proxetil was considered noninferior to the active control (88.7% versus 88.4% respectfully) in the treatment of canine skin infections (wounds and abscesses) caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis (group G, β hemolytic), Escherichia coli, Pasteurella multocida , and Proteus mirabilis .
ANIMAL SAFETY
In target animal safety studies, cefpodoxime was well tolerated at exaggerated daily oral doses of 100 mg/kg/day (10 times the maximum label dose) for 13 weeks in adult dogs and for 28 days in puppies (18-23 days of age). Therefore, once daily administration of cefpodoxime oral tablets at the maximum labeled dose of 10 mg/kg for up to 28 days was shown to be safe in adult dogs and puppies.
Blood dyscrasia including neutropenias, may be seen following high doses of cephalosporins. Cephalosporin administration should be discontinued in such cases.
STORAGE INFORMATION
Store at controlled room temperature 68-77 °F (20-25°C). Replace cap securely after each opening.
HOW SUPPLIED
Cefpodoxime Proxetil Tablets are available in the following strengths (cefpodoxime equivalent), colors, and sizes:
100 mg (yellow, scored, elliptical, debossed with PV on one side, 17 on the other side)
Bottles of 100 ??¦??¦??¦??¦??¦??¦??¦ NDC 26637-331-10
200 mg (orange, oblong, debossed with with PV on one side, 18 on the other side)
Bottles of 100 ??¦??¦??¦??¦??¦??¦??¦ NDC 26637-332-10
ANADA # 200-543, Approved by FDA
Manufactured for:
Putney, Inc.
Portland, ME 04101 USA
1-866-683-0660
Made in Austria
May 2012
NDC26637-331-10
Cefpodoxime Proxetil Tablets
100 mg
Antimicrobial For Oral Use
USE IN DOGS ONLY
100 TABLETS
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
ANADA 200-543, Approved by FDA
100 mg Tablet Bottle
Manufactured for:
Putney, Inc.
Portland, ME 04101 USA
Made in Austria
Cefpodoxime Proxetil Tablets 100 mg
Antimicrobial for Oral Use
USE IN DOGS ONLY
Case Qty.: 40 bottles
100 Tablets per bottle
Keep tightly closed. Store at controlled room temperature, 68-77 °F (20-25°C).
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
46091226
EXP:
LOT:
100 mg Tablet Shipper Label
NDC26637-332-10
Cefpodoxime Proxetil Tablets
200 mg
Antimicrobial For Oral Use
USE IN DOGS ONLY
100 TABLETS
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
ANADA 200-543, Approved by FDA
200 mg Tablet Bottle
Manufactured for:
Putney, Inc.
Portland, ME 04101 USA
Made in Austria
Cefpodoxime Proxetil Tablets 200 mg
Antimicrobial for Oral Use
USE IN DOGS ONLY
Case Qty.: 40 bottles
100 Tablets per bottle
Keep tightly closed. Store at controlled room temperature, 68-77 °F (20-25°C).
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
46091227
EXP:
LOT:
200 mg Tablet Shipper
Autor Name: Putney, Inc.
Code Source: 26637-332
Route of Administration: oral
Cefpodoxime Proxetil
Generic: cefpodoxime proxetilIngredients:
- CEFPODOXIME PROXETIL CEFPODOXIME : Active ingredient - moiety is basis of strength - 100 mg in 1 1
Package Description:
- 100 1 in 1 BOTTLE, PLASTIC
Cefpodoxime Proxetil
Generic: cefpodoxime proxetilIngredients:
- CEFPODOXIME PROXETIL CEFPODOXIME : Active ingredient - moiety is basis of strength - 200 mg in 1 1
Package Description:
- 100 1 in 1 BOTTLE, PLASTIC
Cefpodoxime Proxetil Tablets
For Oral Use in Dogs Only
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
DESCRIPTION
Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic cephalosporin antibiotic. The chemical name is: (+/-)-1-Hydroxyethyl(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 7 2 -(Z)-(0-methyloxime), isopropyl carbonate (ester) [87239-81-4].
Cefpodoxime Proxetil Chemical Structure:
Cefpodoxime proxetil is a prodrug; its active metabolite is cefpodoxime. All doses of Cefpodoxime Proxetil Tablets are expressed in terms of the active cefpodoxime moiety. Cepodoximine Proxitel Tablets are available as:
100 mg Tablet, each yellow, elliptical, scored tablet contains cefpodoxime proxetil equivalent to 100 mg of cefpodoxime.
200 mg Tablet, each orange, oblong, tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime.
Chemical Structure
INDICATIONS
Cefpodoxime Proxetil Tablets are indicated for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius , Staphylococcus aureus , Streptococcus canis (group G, β hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.
DOSAGE AND ADMINISTRATION
Dose Range: The dose range of Cefpodoxime Proxetil Tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.
Duration: Cefpodoxime Proxetil Tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections shouldnot be continued for more than 3-4 days if no response to therapy is seen.
Dosing Charts: For daily oral administration of Cefpodoxime Proxetil Tablets at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).
| Weight of Dogs (lbs) | ||||||
| Daily Dose | 22 | 44 | 66 | 88 | 132 | |
| No. 100 mg tablets | 0.5 | 1 | 1.5 | 1 | ||
| No. 200 mg tablets | 1 | 1 | ||||
| Weight of Dogs (kgs) | ||||||
| Daily Dose | 10 | 20 | 30 | 40 | 60 | |
| No. 100 mg tablets | 0.5 | 1 | 1.5 | 1 | ||
| No. 200 mg tablets | 1 | 1 |
| Weight of Dogs (lbs) | ||||||
| Daily Dose | 11 | 22 | 44 | 66 | 88 | 132 |
| No. 100 mg tablets | 0.5 | 1 | 1 | |||
| No. 200 mg tablets | 1 | 1 | 2 | 3 | ||
| Weight of Dogs (kgs) | ||||||
| Daily Dose | 5 | 10 | 20 | 30 | 40 | 60 |
| No. 100 mg tablets | 0.5 | 1 | 1 | |||
| No. 200 mg tablets | 1 | 1 | 2 | 3 |
CONTRAINDICATIONS
Cefpodoxime proxetil is contraindicated in dogs with known allergy to cefpodoxime or to the β-lactam (penicillins and cephalosporins) group of antibiotics.
WARNINGS
Not for human use. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.
PRECAUTIONS
The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs ` test.
ADVERSE REACTIONS
A total of 216 dogs of various breeds and ages ranging from 2 months to 15 years were included in the field study safety analysis. The following table shows the number of dogs displaying each clinical observation.
| Clinical Observation | Cefpodoxime Proxetil (n=118) | Active Control (n=98) |
| Vomiting | 2 | 4 |
| Diarrhea | 1 | 1 |
| Increased water drinking | 2 | |
| Decreased appetite | 1 | 1 |
To report a suspected adverse reaction call 1-866-683-0660.
To request a Material Safety Data Sheet (MSDS) for Cefpodomixe Proxetil Tablets, call 1-866-683-0660.
CLINICAL PHARMACOLOGY
Pharmacokinetics/Pharmacodynamics: Cefpodoxime proxetil is a prodrug that is absorbed from and de-esterified in the gastrointestinal tract to its active metabolite, cefpodoxime. Following oral administration to fasting Beagles, oral bioavailability was 63.1 ± 5.3%.
Figure 1. Canine Plasma Concentration Of Cefpodoxime After A Single Oral Dose Of 10 mg/kg Cefpodoxime Proxetil Tablets
Cefpodoxime is distributed in the body with an apparent volume of distribution of 151 ± 27 mL/kg. Like other β-lactam antibiotics, cefpodoxime is eliminated from the body primarily in the urine, with an apparent elimination half-life of approximately 5-6 hours after oral administration. This is similar to the 4.7 hour apparent elimination half-life observed after intravenous dosing . Following intravenous administration of 10 mg/kg, the average total body clearance (Cl B ) was 22.7 ± 4.19 mL/hr/kg.
| PK Parameter | Unit | Tablet (SD) |
| AUC 0- ??? | mcg ·hr/mL | 145 (77.6) |
| AUC 0-LOQ | mcg ·hr/mL | 142 (77.5) |
| Maximum concentration (C max ) | mcg/mL | 16.4 (11.8) |
| Terminal plasma elimination half-life (t 1/2,z ) | hr | 5.61 (1.15) |
| Time of maximum concentration (t max ) | hr | 2.21 (0.542) |
| Mean residence time (MRT 0- ??? ) | hr | 9.21 (1.97) |
Cefpodoxime has a broad spectrum of clinically useful antibacterial activity that includes staphylococci, streptococci, and Gram-negative species (including Pasteurella, Escherichia, and Proteus ). The compound is not active against most obligate anaerobes, Pseudomonas spp., or enterococci. The minimum inhibitory concentrations (MICs) for cefpodoxime against Gram-positive and Gram-negative pathogens isolated from canine skin infections (wounds and abscesses) in a 2002 U.S. field study are presented in Table 5. All MICs were determined in accordance with the National Committee for Clinical Laboratory Standards (NCCLS). Appropriate quality control (QC) ranges for in vitro susceptibility testing are presented in Table 6.
| Organism* | # of Isolates | MIC 50 | MIC 90 | Range |
| Staphylococcus intermedius | 118 | 0.12 | 0.50 | 0.12- > 32.0 |
| Streptococcus canis (group G, β hemolytic) | 33 | ≤0.03 | ≤0.03 | ≤0.03 † |
| Escherichia coli | 41 | 0.25 | 0.50 | 0.12- > 32.0 |
| Pasteurella multocida | 32 | ≤0.03 | ≤0.03 | ≤0.03-0.12 |
| Proteus mirabalis | 14 | ≤0.03 | 0.06 | ≤0.03-0.06 |
| Staphylococcus aureus | 19 | 2.0 | 2.0 | 0.12-2.0 |
*Veterinary specific interpretive criteria have not been established for the above listed canine pathogens by the NCCLS at this time.
| QC ATCC strain | KB Disk Diffusion Method | Broth Micro-dilution Method | |
| Drug concentration | Zone diameter | MIC | |
| Escherichia coli 25922 | 10 mcg | 23-28 mm a | 0.25-1 mcg/mL a |
| Staphylococcus aureus 25923 | 10 mcg | 19-25 mm a | |
| Staphylococcus aureus 29213 | 1-8 mcg/mL a | ||
| Staphylococcus pneumoniae 49619 | 10 mcg | 28-34 mm b | 0.03-0.12 mcg/mL b |
b These ranges are for quality control strains used to monitor accuracy of minimum inhibitory concentrations (MICs) of fastidious organisms. When susceptibility testing is performed for Streptococcus canis (group G, β hemolytic), Streptococcus pneumoniae ATCC 49619 should be included as a QC strain in the presence of 5% lysed sheep blood (KB disk diffusion method) or 2.5% lysed horse blood (broth micro-dilution method).
Figure 1 PK
EFFECTIVENESS
The clinical effectiveness of cefpodoxime proxetil was established in a multi-location (23 site) field study. In this study, 216 dogs with infected wounds or abscesses were treated with either cefpodoxime proxetil (n=118) once daily at 5 mg/kg (2.3 mg/lb) body weight or with a active control antibiotic (n=98) administered twice daily for 5-7 days. In this study, cefpodoxime proxetil was considered noninferior to the active control (88.7% versus 88.4% respectfully) in the treatment of canine skin infections (wounds and abscesses) caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis (group G, β hemolytic), Escherichia coli, Pasteurella multocida , and Proteus mirabilis .
ANIMAL SAFETY
In target animal safety studies, cefpodoxime was well tolerated at exaggerated daily oral doses of 100 mg/kg/day (10 times the maximum label dose) for 13 weeks in adult dogs and for 28 days in puppies (18-23 days of age). Therefore, once daily administration of cefpodoxime oral tablets at the maximum labeled dose of 10 mg/kg for up to 28 days was shown to be safe in adult dogs and puppies.
Blood dyscrasia including neutropenias, may be seen following high doses of cephalosporins. Cephalosporin administration should be discontinued in such cases.
STORAGE INFORMATION
Store at controlled room temperature 68-77 °F (20-25°C). Replace cap securely after each opening.
HOW SUPPLIED
Cefpodoxime Proxetil Tablets are available in the following strengths (cefpodoxime equivalent), colors, and sizes:
100 mg (yellow, scored, elliptical, debossed with PV on one side, 17 on the other side)
Bottles of 100 ??¦??¦??¦??¦??¦??¦??¦ NDC 26637-331-10
200 mg (orange, oblong, debossed with with PV on one side, 18 on the other side)
Bottles of 100 ??¦??¦??¦??¦??¦??¦??¦ NDC 26637-332-10
ANADA # 200-543, Approved by FDA
Manufactured for:
Putney, Inc.
Portland, ME 04101 USA
1-866-683-0660
Made in Austria
May 2012
Putney ©
NDC26637-331-10
Cefpodoxime Proxetil Tablets
100 mg
Antimicrobial For Oral Use
USE IN DOGS ONLY
100 TABLETS
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
ANADA 200-543, Approved by FDA
100 mg Tablet Bottle
PRINCIPAL DISPLAY PANEL - 100 mg Tablet Shipper Label
Putney ©Manufactured for:
Putney, Inc.
Portland, ME 04101 USA
Made in Austria
Cefpodoxime Proxetil Tablets 100 mg
Antimicrobial for Oral Use
USE IN DOGS ONLY
Case Qty.: 40 bottles
100 Tablets per bottle
Keep tightly closed. Store at controlled room temperature, 68-77 °F (20-25°C).
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
46091226
EXP:
LOT:
100 mg Tablet Shipper Label
PRINCIPAL DISPLAY PANEL - 200 mg Tablet Bottle Label
Putney ©NDC26637-332-10
Cefpodoxime Proxetil Tablets
200 mg
Antimicrobial For Oral Use
USE IN DOGS ONLY
100 TABLETS
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
ANADA 200-543, Approved by FDA
200 mg Tablet Bottle
PRINCIPAL DISPLAY PANEL - 200 mg Tablet Shipper Label
Putney ©Manufactured for:
Putney, Inc.
Portland, ME 04101 USA
Made in Austria
Cefpodoxime Proxetil Tablets 200 mg
Antimicrobial for Oral Use
USE IN DOGS ONLY
Case Qty.: 40 bottles
100 Tablets per bottle
Keep tightly closed. Store at controlled room temperature, 68-77 °F (20-25°C).
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
46091227
EXP:
LOT:
200 mg Tablet Shipper