Doses - GUAIFENESIN

Dogs:

a) Guaifenesin only: 44 - 88 mg/kg IV; or guaifenesin 33 - 88 mg/kg IV with 2.2 - 6.6 mg/kg thiamylal or 1.1 mg/kg ketamine (Muir )
b) 110 mg/kg IV for muscle relaxation during certain toxicoses (e.g., strychnine) or tetanus (Morgan 1988), (Bailey 1986a)
c) For chemical restraint for ventilatory support: Combination of guaifenesin 50 mg/ml, ketamine 1 mg/ml, & xylazine 0.25 mg/ml; give 0.55 ml bolus initially followed by 2.2 ml/kg/hr thereafter (Pascoe 1986)

Cattle:

a) Guaifenesin only: 66 - 132 mg/kg IV; or guaifenesin 44 - 88 mg/kg IV with 2.2 - 6.6 mg/kg thiamylal or 0.66 - 1.1 mg/kg ketamine (Muir )
b) 55 - 110 mg/kg IV (Mandsager 1988)

Horses:

a) 110 mg/kg IV, give first 1/3-1/2 of dose until horse falls gently, then give remainder unless respiratory or cardiovascular effects are observed. (Package Insert, Guailaxin® - Robins)
b) Guaifenesin only: 66 - 132 mg/kg IV; or guaifenesin 44 - 88 mg/kg IV with 2.2 - 6.6 mg/kg thiamylal (Muir )
c) 55 - 110 mg/kg IV (Mandsager 1988)
d) For anesthesia: 100 mg/kg IV combined with barbiturate in 5% dextrose. As an expectorant: 3 mg/kg PO (Robinson 1987)

Swine:

a) Guaifenesin only: 44 - 88 mg/kg IV; or guaifenesin 33 - 88 mg/kg IV with 2.2 - 6.6 mg/kg thiamylal or 1.1 mg/kg ketamine (Muir )
Goats:a) Guaifenesin only: 66 - 132 mg/kg IV; or guaifenesin 44 - 88 mg/kg IV with 0.66 - 1.1 mg/kg ketamine (Muir )
Monitoring Parameters -

1) Level of muscle relaxation

2) Cardiac and respiratory rate
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Guaifenesin Sterile Powder for Injection 50 gram for reconstitution in 4 oz and 32 oz containers;
Guailaxin® (Fort Dodge), Gecolate® (Summit Hill); (Rx) Approved for use in horses.
Guaifenesin Injection 50mg/ml 1000ml; Gecolate® (Summit Hill); generic (Phoenix); (Rx)
Approved for use in horses.
Human-Approved Products: No parenteral preparations are approved. There are many OTC oral expectorant/cough preparations on the market.